gene detail

Gene description

TAIR ID: AT5G14200

Short description: isopropylmalate dehydrogenase 1

Pathogen responsiveness: NA

General responsiveness: NA

Orthologous

Rice: No orthologous gene

Maize: No orthologous gene

Wheat: No orthologous gene

GO biological process

leucine biosynthetic process, response to salt stress, glucosinolate biosynthetic process, oxidation-reduction process

GO cellular component

chloroplast, chloroplast stroma, cytoplasm, plastid

GO molecular function

NAD binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, 3-isopropylmalate dehydrogenase activity, magnesium ion binding

Protein domain

Pfam	PF00180, Isocitrate/isopropylmalate dehydrogenase
SMART	SM01329, Iso_dh

Metabolic pathway

LEUSYN-PWY: leucine biosynthesis
BRANCHED-CHAIN-AA-SYN-PWY: superpathway of leucine, valine, and isoleucine biosynthesis
PWYQT-4450: aliphatic glucosinolate biosynthesis, side chain elongation cycle

KEGG pathway

PATH:ath01210: 2-Oxocarboxylic acid metabolism
PATH:ath00290: Valine, leucine and isoleucine biosynthesis
PATH:ath00966: Glucosinolate biosynthesis

Transcriptional regulation

Regulator:
AT5G13790, AT4G18770, AT2G20180, AT5G61850, AT4G36990

Target:
none

Protein-protein interaction network

The number of partners (degree) is: 1

click to view PPI network

Coexpression network

GSE45212_WT_PSTDC3000_AVRRPT2  view
GSE56094_WT_HRPA-  view
GSE56094_WT_PSTDC3000  view
GSE45212_MED14_PSTDC3000_AVRRPT2  view

Differentially expressed condition

13 conditions

Series	Control	Treatment	Log₂FC	Adj. P value
GSE37269	Ei2, WT, control	Ei2, WT, TEV 21 d	-2.15	5.50E-04
GSE45212	Col, WT, PstDC3000 AvrRpt2 0 h	Col, WT, PstDC3000 AvrRpt2 12 h	-2.50	3.25E-08
GSE45212	Col, med14, PstDC3000 AvrRpt2 0 h	Col, med14, PstDC3000 AvrRpt2 12 h	-2.45	4.71E-08
GSE45212	Col, med14, PstDC3000 AvrRpt2 0 h	Col, med14, PstDC3000 AvrRpt2 4 h	-1.85	2.09E-06
GSE45212	Col, med14, PstDC3000 AvrRpt2 0 h	Col, med14, PstDC3000 AvrRpt2 8 h	-2.94	2.97E-09
GSE45214	Col, WT, PstDC3000 AvrRpt2 0 h	Col, WT, PstDC3000 AvrRpt2 4 h	-1.69	1.72E-09
GSE45214	Col, med16, PstDC3000 AvrRpt2 0 h	Col, med16, PstDC3000 AvrRpt2 4 h	-1.54	3.52E-09
GSE56094	Col, WT, control 10 h	Col, WT, PstDC3000 10 h	-3.36	6.10E-14
GSE56094	Col, WT, control 10 h	Col, WT, hrpA- 10 h	-1.62	2.55E-04
GSE56094	Col, WT, control 11 h	Col, WT, PstDC3000 11 h	-2.05	1.40E-06
GSE56094	Col, WT, control 12 h	Col, WT, PstDC3000 12 h	-2.58	2.61E-09
GSE56094	Col, WT, control 13 h	Col, WT, PstDC3000 13 h	-2.74	2.70E-10
GSE56094	Col, WT, control 9 h	Col, WT, PstDC3000 9 h	-1.55	2.92E-04