Gene: AT1G74040
Gene description
TAIR ID: AT1G74040
Short description: 2-isopropylmalate synthase 1
Pathogen responsiveness: -1.69
General responsiveness: -1.08
Orthologous
Rice:
Maize:
Wheat: No orthologous gene
GO biological process
leucine biosynthetic process, carboxylic acid metabolic process
GO cellular component
chloroplast envelope, chloroplast
GO molecular function
lyase activity, 2-isopropylmalate synthase activity, transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
Protein domain
| Pfam | PF08502, LeuA allosteric (dimerisation) domain |
| Pfam | PF00682, HMGL-like |
| SMART | SM00917, LeuA_dimer |
Metabolic pathway
LEUSYN-PWY: leucine biosynthesis
BRANCHED-CHAIN-AA-SYN-PWY: superpathway of leucine, valine, and isoleucine biosynthesis
KEGG pathway
PATH:ath01210: 2-Oxocarboxylic acid metabolism
PATH:ath01230: Biosynthesis of amino acids
PATH:ath00620: Pyruvate metabolism
PATH:ath00290: Valine, leucine and isoleucine biosynthesis
Transcriptional regulation
No regulation information
click to view PPI networkCoexpression network
Differentially expressed condition 
5 conditions
| Series | Control | Treatment | Log2FC | Adj. P value |
|---|---|---|---|---|
| GSE18978 | Col, WT, control 24 h | Col, WT, PsmES4326 24 h | -2.06 | 2.94E-09 |
| GSE37269 | St0, WT, control | St0, WT, TEV 21 d | -1.51 | 1.18E-02 |
| GSE45212 | Col, WT, PstDC3000 AvrRpt2 0 h | Col, WT, PstDC3000 AvrRpt2 12 h | -1.69 | 2.22E-13 |
| GSE45212 | Col, med14, PstDC3000 AvrRpt2 0 h | Col, med14, PstDC3000 AvrRpt2 12 h | -1.66 | 2.94E-13 |
| GSE45212 | Col, med14, PstDC3000 AvrRpt2 0 h | Col, med14, PstDC3000 AvrRpt2 8 h | -1.72 | 1.56E-13 |
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