Protein description
Entry name: TCAM1_HUMAN
Gene ID: 148022
Gene name: TICAM1;PRVTIRB;TRIF
Protein name: TIR domain-containing adapter molecule 1
Homologous
InparanoidQ8IUC6
OMAYNFVVLH
GO biological process
apoptotic signaling pathway [GO:0097190]
cellular response to lipopolysaccharide [GO:0071222]
cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]
defense response to virus [GO:0051607]
I-kappaB kinase/NF-kappaB signaling [GO:0007249]
inflammatory response [GO:0006954]
innate immune response [GO:0045087]
lipopolysaccharide-mediated signaling pathway [GO:0031663]
macrophage activation involved in immune response [GO:0002281]
MyD88-independent toll-like receptor signaling pathway [GO:0002756]
necroptotic process [GO:0070266]
negative regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034128]
positive regulation of autophagy [GO:0010508]
positive regulation of B cell proliferation [GO:0030890]
positive regulation of chemokine biosynthetic process [GO:0045080]
positive regulation of cytokine production involved in inflammatory response [GO:1900017]
positive regulation of gene expression [GO:0010628]
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]
positive regulation of interferon-beta biosynthetic process [GO:0045359]
positive regulation of interleukin-6 production [GO:0032755]
positive regulation of myeloid dendritic cell cytokine production [GO:0002735]
positive regulation of natural killer cell activation [GO:0032816]
positive regulation of NF-kappaB transcription factor activity [GO:0051092]
positive regulation of nitric oxide biosynthetic process [GO:0045429]
positive regulation of protein binding [GO:0032092]
positive regulation of protein ubiquitination [GO:0031398]
positive regulation of tumor necrosis factor production [GO:0032760]
regulation of protein-containing complex assembly [GO:0043254]
response to exogenous dsRNA [GO:0043330]
toll-like receptor 3 signaling pathway [GO:0034138]
TRIF-dependent toll-like receptor signaling pathway [GO:0035666]
viral process [GO:0016032]
GO cellular component
autophagosome [GO:0005776]
cytosol [GO:0005829]
endosome membrane [GO:0010008]
mitochondrion [GO:0005739]
ripoptosome [GO:0097342]
GO molecular function
protein kinase binding [GO:0019901]
Subcellular localization
Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:21695056}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q80UF7}. Mitochondrion {ECO:0000250|UniProtKB:Q80UF7}.
Protein domain
Pfam
PF12721;PF17798
Interpro
IPR025735;IPR017278;IPR035897;IPR040886
PDB
2M1X  2M63  3RC4  4BSX  4C0M  5JEL  
Complex structure
HumanVirusPDB/TemplateChain_HChain_VIdentity_HCoverage_HIdentity_VCoverage_VStructure_SourceDetail
Q8IUC6P279583rc4ABNANANANAExperimentally verified structureView
Metabolic pathway
R-HSA-140534;R-HSA-166166;R-HSA-168164;R-HSA-168927;R-HSA-1810476;R-HSA-2562578;R-HSA-5602566;R-HSA-5602571;R-HSA-9013957;R-HSA-9013973;R-HSA-9014325;R-HSA-936964;R-HSA-937041;R-HSA-937072;R-HSA-975163
KEGG pathway
hsa:148022
Pathway:  hsa04064:  NF-kappa B signaling pathway
Pathway:  hsa04217:  Necroptosis
Pathway:  hsa04620:  Toll-like receptor signaling pathway
Pathway:  hsa04621:  NOD-like receptor signaling pathway
Pathway:  hsa05235:  PD-L1 expression and PD-1 checkpoint pathway in cancer
Pathway:  hsa05135:  Yersinia infection
Pathway:  hsa05133:  Pertussis
Pathway:  hsa05164:  Influenza A
Pathway:  hsa05161:  Hepatitis B
Pathway:  hsa05160:  Hepatitis C
Pathway:  hsa05168:  Herpes simplex virus 1 infection
Pathway:  hsa05167:  Kaposi sarcoma-associated herpesvirus infection
Pathway:  hsa05165:  Human papillomavirus infection
Pathway:  hsa05142:  Chagas disease (American trypanosomiasis)
KO:  K05842:TRIF:  toll-like receptor adapter molecule 1
Protein-protein interaction network
Click here to view specific interaction information
SNP
rs11466719;rs146550489;rs11466721;rs11466724
Differentially expressed condition
SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE101760mock_infectedPR8_NS1_infectedup2.221.40e-02RNA-Seq data
GSE102924controlZIKV-Brazil_Dakar_strainsup1.784.13e-07RNA-Seq data
GSE61141non-asthmatic_Vehiclenon-asthmatic_HRV16up1.685.23e-13RNA-Seq data
GSE75699HNBE_control_0hHNBE_infected_24hup1.571.29e-04RNA-Seq data
GSE27702control_macrophagesFPV-infected_macrophagesdown-1.618.21e-03Microarray data
GSE32140-GPL6480mock_for_RSV_2hRSV_infectionup2.543.62e-06Microarray data
GSE32140-GPL6947mock_for_influenza_2hinfluenza_infection_2hup3.141.59e-03Microarray data
GSE32155CRL-5800_unifectedCRL-5807_infecteddown-2.128.51e-05Microarray data
GSE32155CRL-5810_unifectedCRL-1472_infectedup3.964.63e-02Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_Anhui01_pCalu3_24hup2.124.90e-08Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_Pan99_pCalu3_24hup1.883.66e-06Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hup1.592.97e-06Microarray data
GSE65574MCL001_mock_24hMCL001_d3-5-MERS_24hup1.512.83e-04Microarray data
GSE99298mock_infected_0hhRSV_WT_infected_96hup2.016.39e-07RNA-Seq data
GSE89008HTBE_H1N1_MOI0_mock_infected_3hHTBE_H1N1_MOI5_infected_3hup1.621.63e-04RNA-Seq data
GSE89008HTBE_H5N1_MOI0_mock_infected_18hHTBE_H5N1_MOI5_infected_18hdown-1.564.85e-02RNA-Seq data
GSE97672-GPL16791MDM-315_H1N1_MOI0_18hMDM-315_H1N1_MOI2_18hup1.529.40e-08RNA-Seq data
GSE97672-GPL16791MDM-513_H5N1_MOI0_06hMDM-513_H5N1_MOI2_06hdown-1.601.45e-05RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_12hMDM-520_H5N1_MOI2_12hdown-1.784.74e-09RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-1.974.56e-06RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_12hMDM-513_H5N1_MOI2_12hdown-1.733.67e-04RNA-Seq data
GSE980monocyte-derived_dendritic_cells_controlMV-infected_dendritic_cells_24hup1.535.51e-03Microarray data