Protein description
Entry name: MAVS_HUMAN
Gene ID: 57506
Gene name: MAVS;IPS1;KIAA1271;VISA
Protein name: Mitochondrial antiviral-signaling protein
Homologous
InparanoidQ7Z434
OMAHNGYREE
GO biological process
activation of innate immune response [GO:0002218]
cellular response to exogenous dsRNA [GO:0071360]
defense response to bacterium [GO:0042742]
defense response to virus [GO:0051607]
innate immune response [GO:0045087]
negative regulation of type I interferon production [GO:0032480]
negative regulation of viral genome replication [GO:0045071]
positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]
positive regulation of defense response to virus by host [GO:0002230]
positive regulation of DNA-binding transcription factor activity [GO:0051091]
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]
positive regulation of interferon-alpha production [GO:0032727]
positive regulation of interferon-alpha secretion [GO:1902741]
positive regulation of interferon-beta production [GO:0032728]
positive regulation of interferon-beta secretion [GO:0035549]
positive regulation of interleukin-6 secretion [GO:2000778]
positive regulation of interleukin-8 production [GO:0032757]
positive regulation of IP-10 production [GO:0071660]
positive regulation of myeloid dendritic cell cytokine production [GO:0002735]
positive regulation of protein import into nucleus [GO:0042307]
positive regulation of protein phosphorylation [GO:0001934]
positive regulation of response to cytokine stimulus [GO:0060760]
positive regulation of transcription by RNA polymerase II [GO:0045944]
positive regulation of tumor necrosis factor production [GO:0032760]
positive regulation of tumor necrosis factor secretion [GO:1904469]
positive regulation of type I interferon-mediated signaling pathway [GO:0060340]
regulation of peroxisome organization [GO:1900063]
signal transduction [GO:0007165]
viral process [GO:0016032]
GO cellular component
integral component of membrane [GO:0016021]
mitochondrial membrane [GO:0031966]
mitochondrial outer membrane [GO:0005741]
mitochondrion [GO:0005739]
peroxisomal membrane [GO:0005778]
GO molecular function
CARD domain binding [GO:0050700]
protein kinase binding [GO:0019901]
signaling adaptor activity [GO:0035591]
Subcellular localization
Mitochondrion outer membrane {ECO:0000269|PubMed:16125763}. Mitochondrion {ECO:0000269|PubMed:11780052, ECO:0000269|PubMed:17709747}. Peroxisome {ECO:0000269|PubMed:20451243}.
Protein domain
Pfam
PF16739
Interpro
IPR031964;IPR042144;IPR026148
CDD
cd08811
PDB
2MS7  2MS8  2VGQ  3J6C  3J6J  3RC5  4P4H  4Z8M  5JEK  
Complex structure
HumanVirusPDB/TemplateChain_HChain_VIdentity_HCoverage_HIdentity_VCoverage_VStructure_SourceDetail
Q7Z434P279583rc5ABNANANANAExperimentally verified structureView
Metabolic pathway
R-HSA-168928;R-HSA-5689896;R-HSA-918233;R-HSA-933541;R-HSA-933542;R-HSA-933543;R-HSA-936440
KEGG pathway
hsa:57506
Pathway:  hsa04621:  NOD-like receptor signaling pathway
Pathway:  hsa04622:  RIG-I-like receptor signaling pathway
Pathway:  hsa04623:  Cytosolic DNA-sensing pathway
Pathway:  hsa05162:  Measles
Pathway:  hsa05164:  Influenza A
Pathway:  hsa05161:  Hepatitis B
Pathway:  hsa05160:  Hepatitis C
Pathway:  hsa05168:  Herpes simplex virus 1 infection
Pathway:  hsa05169:  Epstein-Barr virus infection
KO:  K12648:MAVS:  mitochondrial antiviral-signaling protein
Protein-protein interaction network
Click here to view specific interaction information
SNP
rs11905552;rs11908032;rs17857295;rs7262903;rs7269320
Differentially expressed condition
SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE13637HUVEC_controlPR8-infected_IKK2kd-transfected_HUVECdown-1.869.39e-05Microarray data
GSE13637HUVEC_controlPR8-infected_pEGZ-transfected_HUVECdown-1.851.04e-04Microarray data
GSE27702control_macrophagesFPV-infected_macrophagesdown-2.743.73e-03Microarray data
GSE27702control_macrophagesH5N1-infected_macrophagesdown-1.912.55e-03Microarray data
GSE30723AMs_control_24hAMs_PR8_24hdown-2.184.90e-04Microarray data
GSE31524H1N1_Mock_infection_10hH1N1_infection_10hdown-1.858.61e-06Microarray data
GSE32140-GPL6480mock_for_RSV_2hRSV_infectiondown-1.843.39e-05Microarray data
GSE32155CRL-5800_unifectedCRL-1472_infectedup1.728.58e-05Microarray data
GSE32155HTB-3_unifectedHTB-174_infecteddown-1.633.57e-04Microarray data
GSE32155HTB-4_unifectedHTB-174_infecteddown-2.429.23e-05Microarray data
GSE40711mock_infected_6hIDN3006_or_cl2PA_infected_6hdown-1.541.66e-04Microarray data
GSE45042ELC001_mock_infected_24hECL001_EMC_infected_24hdown-1.764.87e-05Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hdown-1.892.16e-06Microarray data
GSE59226ControlVirus_infectiondown-2.691.14e-04Microarray data
GSE89008HTBE_H5N1_MOI0_mock_infected_12hHTBE_H5N1_MOI5_infected_12hdown-2.069.43e-21RNA-Seq data
GSE89008HTBE_H5N1_MOI0_mock_infected_18hHTBE_H5N1_MOI5_infected_18hdown-2.121.41e-29RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_06hMDM-418_H3N2_MOI2_06hdown-2.651.49e-38RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_12hMDM-418_H3N2_MOI2_12hdown-2.824.61e-05RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_18hMDM-418_H3N2_MOI2_18hdown-2.201.08e-37RNA-Seq data
GSE97672-GPL16791MDM-513_H5N1_MOI0_06hMDM-513_H5N1_MOI2_06hdown-3.104.58e-60RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_06hMDM-520_H5N1_MOI2_06hdown-2.746.63e-45RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_12hMDM-520_H5N1_MOI2_12hdown-3.766.02e-84RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hdown-3.281.46e-53RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-3.652.76e-90RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_12hMDM-513_H5N1_MOI2_12hdown-4.084.77e-92RNA-Seq data