Protein description
Entry name: POLG_HCVH
Protein name: Genome polyprotein
Homologous
InparanoidNA
OMANA
GO biological process
clathrin-dependent endocytosis of virus by host cell [GO:0075512]
fusion of virus membrane with host endosome membrane [GO:0039654]
induction by virus of host autophagy [GO:0039520]
lymphocyte aggregation [GO:0071593]
modulation by virus of host cellular process [GO:0019054]
modulation by virus of host G1/S transition checkpoint [GO:0039645]
modulation by virus of host protein transport [GO:0044833]
modulation by virus of host transcription [GO:0019056]
negative regulation by symbiont of host defense-related protein level [GO:0033663]
negative regulation by symbiont of host protein levels [GO:1990214]
negative regulation of acute inflammatory response [GO:0002674]
negative regulation of ATPase activity [GO:0032780]
negative regulation of B cell proliferation [GO:0030889]
negative regulation of cell death [GO:0060548]
negative regulation of defense response to virus by host [GO:0050689]
negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]
negative regulation of endoribonuclease activity [GO:0060702]
negative regulation of execution phase of apoptosis [GO:1900118]
negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]
negative regulation of interleukin-6 production [GO:0032715]
negative regulation of kinase activity [GO:0033673]
negative regulation of protein autophosphorylation [GO:0031953]
negative regulation of protein secretion [GO:0050709]
negative regulation of release of cytochrome c from mitochondria [GO:0090201]
negative regulation of RNA interference [GO:1900369]
negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]
negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]
negative regulation of toll-like receptor 7 signaling pathway [GO:0034156]
negative regulation of toll-like receptor 9 signaling pathway [GO:0034164]
negative regulation of transcription by RNA polymerase II [GO:0000122]
negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]
negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]
pore formation by virus in membrane of host cell [GO:0039707]
positive regulation by symbiont of host protein levels [GO:1990219]
positive regulation by symbiont of host transcription [GO:1990216]
positive regulation of alkaline phosphatase activity [GO:0010694]
positive regulation of cell growth [GO:0030307]
positive regulation of cell population proliferation [GO:0008284]
positive regulation of cytokinesis [GO:0032467]
positive regulation of gene expression [GO:0010628]
positive regulation of hexokinase activity [GO:1903301]
positive regulation of I-kappaB phosphorylation [GO:1903721]
positive regulation of proteolysis [GO:0045862]
positive regulation of secretion [GO:0051047]
positive regulation of translation [GO:0045727]
positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]
positive regulation of viral process [GO:0048524]
protein complex oligomerization [GO:0051259]
regulation of endoplasmic reticulum unfolded protein response [GO:1900101]
suppression by virus of host apoptotic process [GO:0019050]
suppression by virus of host intracellular interferon activity [GO:0046774]
suppression by virus of host IRF9 activity [GO:0039560]
suppression by virus of host MAVS activity [GO:0039545]
suppression by virus of host NF-kappaB transcription factor activity [GO:0039644]
suppression by virus of host PKR activity [GO:0039580]
suppression by virus of host protein phosphorylation [GO:0039613]
suppression by virus of host STAT1 activity [GO:0039563]
suppression by virus of host TRAF activity [GO:0039547]
suppression by virus of host transcription [GO:0039653]
suppression by virus of host type I interferon-mediated signaling pathway [GO:0039502]
transformation of host cell by virus [GO:0019087]
translocation of peptides or proteins into host cell cytoplasm [GO:0044053]
viral budding from ER membrane [GO:0046762]
viral protein processing [GO:0019082]
viral RNA genome replication [GO:0039694]
virion attachment to host cell [GO:0019062]
GO cellular component
cytoplasmic viral factory [GO:0039714]
endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]
extracellular region [GO:0005576]
host cell cytoplasm [GO:0030430]
host cell cytosol [GO:0044164]
host cell endoplasmic reticulum [GO:0044165]
host cell endoplasmic reticulum membrane [GO:0044167]
host cell Golgi apparatus [GO:0044177]
host cell lipid droplet [GO:0044186]
host cell membrane [GO:0033644]
host cell mitochondrial membrane [GO:0044191]
host cell nucleus [GO:0042025]
host cell perinuclear region of cytoplasm [GO:0044220]
host cell plasma membrane [GO:0020002]
host intracellular organelle [GO:0033647]
integral component of membrane [GO:0016021]
integral to membrane of host cell [GO:0044385]
viral envelope [GO:0019031]
viral nucleocapsid [GO:0019013]
virion membrane [GO:0055036]
GO molecular function
ATPase activity [GO:0016887]
ATPase regulator activity [GO:0060590]
ATP binding [GO:0005524]
cysteine-type endopeptidase activity [GO:0004197]
DEAD/H-box RNA helicase binding [GO:0017151]
enzyme binding [GO:0019899]
heat shock protein binding [GO:0031072]
identical protein binding [GO:0042802]
ion channel activity [GO:0005216]
keratin filament binding [GO:1990254]
kinase binding [GO:0019900]
MHC class I protein binding [GO:0042288]
p53 binding [GO:0002039]
peptidase activity [GO:0008233]
protein phosphatase binding [GO:0019903]
Rab GTPase binding [GO:0017137]
RNA binding [GO:0003723]
RNA-directed 5'-3' RNA polymerase activity [GO:0003968]
RNA helicase activity [GO:0003724]
scavenger receptor binding [GO:0005124]
serine-type endopeptidase activity [GO:0004252]
serine-type peptidase activity [GO:0008236]
SH3 domain binding [GO:0017124]
STAT family protein binding [GO:0097677]
structural molecule activity [GO:0005198]
Toll-like receptor 2 binding [GO:0035663]
transcription factor binding [GO:0008134]
translation initiation factor binding [GO:0031369]
zinc ion binding [GO:0008270]
Subcellular localization
[Core protein p21]: Host endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Host mitochondrion membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Host lipid droplet {ECO:0000250}.
Protein domain
Pfam
PF07652;PF01543;PF01542;PF01539;PF01560;PF01538;PF01006;PF01001;PF01506;PF08300;PF08301;PF12941;PF02907;PF00998
SMART
SM00487;SM00490
Interpro
IPR011492;IPR002521;IPR002522;IPR002519;IPR002531;IPR002518;IPR042205;IPR042209;IPR000745;IPR001490;IPR002868;IPR013193;IPR038568;IPR024350;IPR014001;IPR001650;IPR013192;IPR038170;IPR027417;IPR009003;IPR004109;IPR007094;IPR002166
PDB
1A1R  1A1V  1CWX  1HEI  1JR6  1N1L  1ONB  1R7C  1R7D  1R7E  1R7F  1R7G  1RGQ  2A4R  2F9V  2HD0  2JXF  2KDR  2N1P  2O8M  2OBO  2OBQ  2OC0  2OC1  2OC7  2OC8  2OIN  2P59  2QV1  2XI2  2XI3  2XNI  4CL1  4JZN  4JZO  4MWF  4N0Y  4Q0X  4XVJ  4Z0X  5EOC  5ERW  5FGB  5FGC  5JZI  5YXN  5YXU  6BQJ  6BQK  6BZU  6BZV  6BZW  6BZY  
Complex structure
HumanVirusPDB/TemplateChain_HChain_VIdentity_HCoverage_HIdentity_VCoverage_VStructure_SourceDetail
Q7Z434P279583rc5ABNANANANAExperimentally verified structureView
Q8IUC6P279583rc4ABNANANANAExperimentally verified structureView
P04439P279585yxnCINANANANAExperimentally verified structureView
Metabolic pathway
R-HSA-8854214
KEGG pathway
Not involved in KEGG pathway
Protein-protein interaction network
Click here to view specific interaction information
SNP
NA