Protein description
Entry name: HLAA_HUMAN
Gene ID: 3105
Gene name: HLA-A;HLAA
Protein name: HLA class I histocompatibility antigen
Homologous
InparanoidNA
OMANA
GO biological process
antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]
antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [GO:0002480]
antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]
CD8-positive, alpha-beta T cell activation [GO:0036037]
immune response [GO:0006955]
interferon-gamma-mediated signaling pathway [GO:0060333]
positive regulation of CD8-positive, alpha-beta T cell activation [GO:2001187]
positive regulation of T cell cytokine production [GO:0002726]
protein ubiquitination [GO:0016567]
regulation of immune response [GO:0050776]
T cell mediated cytotoxicity [GO:0001913]
T cell mediated cytotoxicity directed against tumor cell target [GO:0002419]
T cell receptor signaling pathway [GO:0050852]
type I interferon signaling pathway [GO:0060337]
viral process [GO:0016032]
GO cellular component
cell surface [GO:0009986]
early endosome membrane [GO:0031901]
endoplasmic reticulum [GO:0005783]
endoplasmic reticulum membrane [GO:0005789]
ER to Golgi transport vesicle membrane [GO:0012507]
Golgi apparatus [GO:0005794]
Golgi membrane [GO:0000139]
integral component of lumenal side of endoplasmic reticulum membrane [GO:0071556]
integral component of plasma membrane [GO:0005887]
membrane [GO:0016020]
MHC class I peptide loading complex [GO:0042824]
MHC class I protein complex [GO:0042612]
phagocytic vesicle membrane [GO:0030670]
plasma membrane [GO:0005886]
recycling endosome membrane [GO:0055038]
GO molecular function
beta-2-microglobulin binding [GO:0030881]
CD8 receptor binding [GO:0042610]
peptide antigen binding [GO:0042605]
signaling receptor binding [GO:0005102]
TAP binding [GO:0046977]
TAP complex binding [GO:0062061]
T cell receptor binding [GO:0042608]
Subcellular localization
Cell membrane {ECO:0000269|PubMed:21263072, ECO:0000269|PubMed:25880248, ECO:0000269|PubMed:8805302}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:8805302}; Single-pass type I membrane protein {ECO:0000255}.
Protein domain
Pfam
PF07654;PF00129;PF06623
SMART
SM00407
Interpro
IPR007110;IPR036179;IPR013783;IPR003006;IPR003597;IPR011161;IPR037055;IPR011162;IPR001039;IPR010579
PDB
1AKJ  1AO7  1AQD  1B0G  1B0R  1BD2  1DUY  1DUZ  1EEY  1EEZ  1HHG  1HHH  1HHI  1HHJ  1HHK  1HLA  1HSB  1I1F  1I1Y  1I4F  1I7R  1I7T  1I7U  1IM3  1JF1  1JHT  1LP9  1OGA  1P7Q  1Q94  1QEW  1QR1  1QRN  1QSE  1QSF  1QVO  1S8D  1S9W  1S9X  1S9Y  1T1W  1T1X  1T1Y  1T1Z  1T20  1T21  1T22  1TMC  1TVB  1TVH  1UR7  1W72  1X7Q  2AV1  2AV7  2BCK  2BNQ  2BNR  2C7U  2CLR  2F53  2F54  2GIT  2GJ6  2GT9  2GTW  2GTZ  2GUO  2HLA  2HN7  2J8U  2JCC  2P5E  2P5W  2PYE  2UWE  2V2W  2V2X  2VLJ  2VLK  2VLL  2VLR  2X4N  2X4O  2X4P  2X4Q  2X4R  2X4S  2X4T  2X4U  2X70  2XPG  3BGM  3BH8  3BH9  3BHB  3BO8  3D25  3D39  3D3V  3FQN  3FQR  3FQT  3FQU  3FQW  3FQX  3FT2  3FT3  3FT4  3GIV  3GJF  3GSN  3GSO  3GSQ  3GSR  3GSU  3GSV  3GSW  3GSX  3H7B  3H9H  3H9S  3HAE  3HLA  3HPJ  3I6G  3I6K  3I6L  3IXA  3KLA  3MGO  3MGT  3MR9  3MRB  3MRC  3MRD  3MRE  3MRF  3MRG  3MRH  3MRI  3MRJ  3MRK  3MRL  3MRM  3MRN  3MRO  3MRP  3MRQ  3MRR  3MYJ  3NFN  3O3A  3O3B  3O3D  3O3E  3O4L  3PWJ  3PWL  3PWN  3PWP  3QDG  3QDJ  3QDM  3QEQ  3QFD  3QFJ  3QZW  3REW  3RL1  3RL2  3TO2  3UTQ  3UTS  3UTT  3V5D  3V5H  3V5K  3VXM  3VXN  3VXO  3VXP  3VXR  3VXS  3VXU  3W0W  3WL9  3WLB  4E5X  4EMZ  4EN2  4EUP  4F7M  4F7P  4F7T  4FTV  4GKN  4GKS  4HWZ  4HX1  4I48  4I4W  4JFD  4JFE  4JFF  4JFO  4JFP  4JFQ  4K7F  4L29  4L3C  4L3E  4MJ5  4MJ6  4MNQ  4N8V  4NNX  4NNY  4NO0  4NO2  4NO3  4NO5  4NQV  4NQX  4OV5  4QOK  4U6X  4U6Y  4UQ2  4UQ3  4WJ5  4WU5  4WU7  4WUU  5BRZ  5BS0  5C07  5C08  5C09  5C0A  5C0B  5C0C  5C0D  5C0E  5C0F  5C0G  5C0I  5C0J  5D2L  5D2N  5D9S  5DDH  5E00  5E6I  5E9D  5ENW  5EOT  5EU3  5EU4  5EU5  5EU6  5EUO  5F7D  5F9J  5FA3  5FA4  5FDW  5GRD  5GRG  5GSD  5HGA  5HGB  5HGD  5HGH  5HHM  5HHN  5HHO  5HHP  5HHQ  5HYJ  5IRO  5ISZ  5JHD  5JZI  5MEN  5MEO  5MEP  5MEQ  5MER  5N1Y  5N6B  5NHT  5NME  5NMF  5NMG  5NMH  5NMK  5NQK  5SWQ  5TEZ  5W1W  5WJL  5WJN  5WKF  5WKH  5WSH  5WWI  5WWJ  5WWU  5WXC  5WXD  5XOV  5YXN  5YXU  6AM5  6AMT  6AMU  6APN  6AT9  6D78  6D7G  6DKP  6EI2  6ENY  6EQA  6EQB  6EWA  6EWC  6EWO  6G3J  6G3K  6ID4  6MPP  6NCA  6O9B  6O9C  6OPD  6PTB  6PTE  6Q3K  6Q3S  
Complex structure
HumanVirusPDB/TemplateChain_HChain_VIdentity_HCoverage_HIdentity_VCoverage_VStructure_SourceDetail
P04439P097131im3EHNANANANAExperimentally verified structureView
P04439Q3KSS76ncaKZNANANANAExperimentally verified structureView
P04439P181395d2nGHNANANANAExperimentally verified structureView
P04439P595963i6gACNANANANAExperimentally verified structureView
P04439P033662x4uDFNANANANAExperimentally verified structureView
P04439Q6SW593mrbAPNANANANAExperimentally verified structureView
P04439Q034633mrgAPNANANANAExperimentally verified structureView
P04439Q2F4V23mgoJLNANANANAExperimentally verified structureView
P04439Q9Q0U75swqACNANANANAExperimentally verified structureView
P04439P045915nmhACNANANANAExperimentally verified structureView
P04439P689794e5xAGNANANANAExperimentally verified structureView
P04439P045821hhgACNANANANAExperimentally verified structureView
P04439Q07FI14nqxKRNANANANAExperimentally verified structureView
P04439P124991q94DFNANANANAExperimentally verified structureView
P04439P140792av1ACNANANANAExperimentally verified structureView
P04439P067253gsoAPNANANANAExperimentally verified structureView
P04439P045881hhjACNANANANAExperimentally verified structureView
P04439Q9YYU33vxmACNANANANAExperimentally verified structureView
P04439Q3KSU13mrfAPNANANANAExperimentally verified structureView
P04439P046033wl9ACNANANANAExperimentally verified structureView
P04439P034664nqvCNNANANANAExperimentally verified structureView
P04439Q9YYH63givDFNANANANAExperimentally verified structureView
P04439P046021qvoACNANANANAExperimentally verified structureView
P04439Q33CG52x4sACNANANANAExperimentally verified structureView
P04439Q692E03to2ACNANANANAExperimentally verified structureView
P04439Q9YYU83vxnACNANANANAExperimentally verified structureView
P04439Q9YXL34f7mACNANANANAExperimentally verified structureView
P04439P680434mj5ACNANANANAExperimentally verified structureView
P04439Q76ZQ34n8vDFNANANANAExperimentally verified structureView
P04439Q706264i48ACNANANANAExperimentally verified structureView
P04439O118221t1wACNANANANAExperimentally verified structureView
P04439Q9YV123rl1ACNANANANAExperimentally verified structureView
P04439Q773783wlbACNANANANAExperimentally verified structureView
P04439P132853rewACNANANANAExperimentally verified structureView
P04439Q9WPU23vxsACNANANANAExperimentally verified structureView
P04439Q90VU74en2CDNANANANAExperimentally verified structureView
P04439P279585yxnCINANANANAExperimentally verified structureView
P04439Q9DIT63mrmAPNANANANAExperimentally verified structureView
P04439Q9YXY34hwzACNANANANAExperimentally verified structureView
P04439Q9Q0U86j2aACNANANANAExperimentally verified structureView
P04439P033145n6bDFNANANANAExperimentally verified structureView
P04439P177635wkfFHNANANANAExperimentally verified structureView
P04439Q9YXL64f7tDFNANANANAExperimentally verified structureView
P04439Q6YMS45wjnGINANANANAExperimentally verified structureView
P04439Q8BEL55iroILNANANANAExperimentally verified structureView
P04439P0C2134e5xDFNANANANAExperimentally verified structureView
P04439A0A0X9JHC15wwjCFNANANANAExperimentally verified structureView
P04439P129011hhhACNANANANAExperimentally verified structureView
P04439P595951x7qACNANANANAExperimentally verified structureView
P04439O118181s8dACNANANANAExperimentally verified structureView
P04439P045832x4oDFNANANANAExperimentally verified structureView
P04439P034852vllDFNANANANAExperimentally verified structureView
P04439P034075xovDFNANANANAExperimentally verified structureView
P04439P045856j1wACNANANANAExperimentally verified structureView
P04439Q1WDM03mgtACNANANANAExperimentally verified structureView
P04439Q9QAC54k7fACNANANANAExperimentally verified structureView
P04439P046015hgdACNANANANAExperimentally verified structureView
Metabolic pathway
R-HSA-1236974;R-HSA-1236977;R-HSA-164940;R-HSA-198933;R-HSA-6798695;R-HSA-877300;R-HSA-8866654;R-HSA-909733;R-HSA-983170
KEGG pathway
Not involved in KEGG pathway
Protein-protein interaction network
Click here to view specific interaction information
SNP
rs2075684;rs2075684;rs1059423;rs41559117;rs1059449;rs199474430;rs199474436;rs78306866;rs199474457;rs1071742;rs1136688;rs1136692;rs1071743;rs1136695;rs1136697;rs1136700;rs1136702;rs1059488;rs1059509;rs1059516;rs1059520;rs1059526;rs9256983;rs9260156;rs1059542;rs879577815;rs3098019
Differentially expressed condition
SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE84346uninfected_controlHCV_infected_high_ISGup1.681.58e-02RNA-Seq data
GSE32140-GPL6480mock_for_influenza_2hinfluenza_infectionup2.011.23e-05Microarray data
GSE32155CRL-5810_unifectedCRL-1472_infectedup2.672.84e-04Microarray data
GSE32155CRL-5810_unifectedCRL-5807_infectedup2.952.47e-04Microarray data
GSE47865mock_infectedSV_infectedup2.064.82e-07Microarray data
GSE93385K048_mock_infectedK048_ZIKV_infectedup2.281.95e-27RNA-Seq data
GSE59226ControlVirus_infectiondown-1.931.58e-04Microarray data
GSE64605HS_unifectedHS_R70_or_L91_infectedup1.657.90e-06Microarray data
GSE67198uninfected_control150HA_u_per_mL_Sev_infectedup1.811.34e-06Microarray data
GSE99298mock_infected_0hhRSV_NS1_Y125A_infected_96hup2.572.60e-02RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hdown-2.092.61e-22RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-2.536.71e-54RNA-Seq data
GSE8961Mock_infectionHMPV_infection_72hup2.031.94e-05Microarray data