Human protein: PCLO_HUMAN
UniProtID: Q9Y6V0
Gene name(s): PCLO;ACZ;KIAA0559
Protein name: Protein piccolo
Gene ID: 27445
HDF/HRF: NA
Virus protein: POLG_HCVH (HCV-H)
UniProtID: P27958
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| Q9Y6V0-P27958 | PHISTO | 23487458 | protein array |
| Interolog evidence: | none/insignificant. | |
| DDI evidence: | yes (score 0.014). | Show |
| Machine learning evidence: | yes (score 0.056). |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE102481 | mock_infected_18h | RVFV_MP12_infected_18h | up | 2.22 | 8.88e-06 | RNA-Seq data |
| GSE102481 | mock_infected_18h | RVFV_ZH548_infected_18h | up | 2.30 | 4.29e-07 | RNA-Seq data |
| GSE102924 | control | ZIKV-Brazil_Dakar_strains | up | 2.62 | 1.25e-02 | RNA-Seq data |
| GSE84346 | uninfected_control | HCV_infected_low_ISG | up | 2.55 | 8.05e-03 | RNA-Seq data |
| GSE28166 | mock_infected_24h | VN1203_infected_24h | up | 1.90 | 3.57e-04 | Microarray data |
| GSE32155 | CRL-5800_unifected | CRL-1472_infected | down | -1.89 | 1.69e-04 | Microarray data |
| GSE32155 | CRL-5810_unifected | CRL-5807_infected | up | 1.70 | 3.98e-04 | Microarray data |
| GSE99298 | mock_infected_0h | hRSV_WT_infected_96h | down | -1.66 | 4.26e-03 | RNA-Seq data |
| GSE97672-GPL16791 | MDM-418_H3N2_MOI0_12h | MDM-418_H3N2_MOI2_12h | down | -6.58 | 3.18e-02 | RNA-Seq data |
| GSE97672-GPL18573 | MDM-513_H5N1_MOI0_18h | MDM-513_H5N1_MOI2_18h | up | 4.44 | 2.06e-02 | RNA-Seq data |
| GSE93861 | healthy_blood_control | Ebola_infection | down | -1.68 | 4.54e-04 | Microarray data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Tissue enhanced:
| Tissue | Expression (TPM) |
|---|---|
| cerebral cortex | 17.4 |
| Ensembl ID: | ENSG00000186472 |
| Gene description: | Piccolo presynaptic cytomatrix protein |
| Chromosome: | 7 |
| Position | 82754013-83162930 |
| Protein class: | Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nuclear speckles, Plasma membrane |