HVIDB-PPI detail

Q9Y3C1 (NOP16)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: NOP16_HUMAN

UniProtID: Q9Y3C1

Gene name(s): NOP16;CGI-117;HSPC111

Protein name: Nucleolar protein 16

Gene ID: 51491

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q9Y3C1-P27958-PRO_0000037566	HPIDB	23487458	protein array

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	yes (score 0.020).	Show
Machine learning evidence:	yes (score 0.734).

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1337	Nop56p-associated pre-rRNA complex	148	0.05 (7/148)	NA	hu.MAP	View
3735	Nop56p-associated pre-rRNA complex	148	0.03 (5/148)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-1.59	1.22e-05	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	down	-2.03	9.87e-10	RNA-Seq data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-2.43	6.62e-05	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-2.80	1.75e-04	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-2.17	5.81e-05	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	1.56	1.70e-03	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	up	1.56	3.80e-05	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	1.86	2.06e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-1.81	1.94e-06	Microarray data
GSE65574	MCL001_mock_0h	MCL001_d3-5-MERS_0h	down	-2.02	4.82e-02	Microarray data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	down	-2.37	1.06e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-3.29	1.24e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-2.53	1.46e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	up	1.55	2.29e-02	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-1.97	3.51e-02	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-2.36	2.63e-20	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.84	8.28e-17	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-3.12	2.20e-19	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	down	-2.67	1.47e-04	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-3.10	1.35e-16	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	down	-2.20	4.31e-09	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-2.75	9.14e-25	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-3.23	1.48e-22	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-3.04	9.42e-17	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-3.42	3.83e-12	RNA-Seq data
GSE93861	healthy_blood_control	Ebola_infection	up	1.72	4.88e-16	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000048162
Gene description:	NOP16 nucleolar protein
Chromosome:	5
Position	176383938-176388975
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleoli