Q9Y237 (PIN4)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: PIN4_HUMAN

UniProtID: Q9Y237

Gene name(s): PIN4

Protein name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

Gene ID: 5303

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q9Y237-P27958PHISTO23487458protein array

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: yes (score 0.004). Show
Machine learning evidence: yes (score 0.120).
Combined Score: 0.095


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
2440DNAJC8-ZNF207-PIN430.67 (2/3)NAhu.MAPView
3573CUTC-DNAJC8-ZNF207-PIN440.50 (2/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE28166mock_infected_24hVN1203_infected_24hup2.011.35e-03Microarray data
GSE32140-GPL6480mock_for_RSV_2hRSV_infectiondown-1.992.27e-05Microarray data
GSE32155CRL-5810_unifectedCRL-5807_infecteddown-1.888.22e-04Microarray data
GSE32155HTB-3_unifectedHTB-174_infectedup1.911.56e-03Microarray data
GSE32155HTB-4_unifectedHTB-174_infecteddown-2.143.04e-04Microarray data
GSE65123healthy_seronegative_controlHCV_infecteddown-3.164.42e-02Microarray data
GSE99298mock_infected_0hhRSV_NS1_Y125A_infected_96hdown-2.086.24e-05RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 12.1 Liver: 13.2 Gallbladder: 10.7 Duodenum: 10.7 Rectum: 13.1 Tonsil: 9.6 Stomach: 8.8 Salivary glanda: 6.1 Adipose tissue: 14.1 Lung: 13.3 Lymph node: 11.2 Pancreas: 1.4 Kidney: 17.8 Colon: 10.8 Appendix: 12.8 Smooth musle: 14.8 Breast: 19.7 Parathyroid gland: 13.4 Esophagus: 6.3 Heart muscle: 8.3 Spleen: 13.5 Skeletal muscle: 6.0 Bone marrow: 5.0 Skin: 9.8 Urinary bladder: 9.5 Cervix, uterine: 15.1 Endometrium: 19.6 Ovary: 16.2 Fallopian tube: 15.1 Seminal vesicle: 13.2 Prostate: 17.8 Epididymis: 24.3 Testis: 7.4 Placenta: 15.8 Thyroid gland: 17.0 Cerebral cortex: 23.0 Adrenal gland: 15.7
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000102309
Gene description:Peptidylprolyl cis/trans isomerase, NIMA-interacting 4
Chromosome:X
Position72181353-72302926
Protein class:Enzymes, Plasma proteins, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Nucleus, Nucleoli