HVIDB-PPI detail

Q9UP65 (PLA2G4C)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: PA24C_HUMAN

UniProtID: Q9UP65

Gene name(s): PLA2G4C

Protein name: Cytosolic phospholipase A2 gamma

Gene ID: 8605

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q9UP65-P27958	biogrid,HPIDB	23015700	affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.035).

Combined Score: 0.021

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE101760	control_infected	PR8_NS1_infected	up	9.66	1.08e-06	RNA-Seq data
GSE101760	mock_infected	PR8_NS1_infected	up	6.68	8.79e-09	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	up	4.05	1.31e-12	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	up	3.68	7.52e-12	RNA-Seq data
GSE102481	mock_infected_9h	RVFV_ZH548_infected_9h	up	2.89	1.19e-02	RNA-Seq data
GSE102924	control	ZIKV-Brazil_Dakar_strains	up	7.59	1.04e-16	RNA-Seq data
GSE64677	mock_infected_72h	WT_infected_72h	up	2.69	6.67e-06	RNA-Seq data
GSE64677	mock_infected_96h	m15_virus_infected_96h	up	4.00	1.39e-12	RNA-Seq data
GSE79968	IMR90_GFP_32h	IMR90_MCPyV_ST_32h	up	3.73	1.92e-02	RNA-Seq data
GSE84285	A549_mock_infected_24h	A549_Dengue_virus_infected_24h	up	2.26	3.70e-44	RNA-Seq data
GSE84285	A549_mock_infected_36h	A549_Dengue_virus_infected_36h	up	4.77	1.10e-78	RNA-Seq data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-1.69	1.53e-02	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	up	1.75	2.51e-04	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	2.01	1.13e-02	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	down	-2.59	1.26e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	down	-1.80	8.00e-04	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	down	-4.79	3.46e-05	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	up	2.91	2.23e-03	Microarray data
GSE47865	mock_infected	SV_infected	up	3.90	9.44e-12	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	up	1.60	7.12e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	2.43	1.26e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	2.05	1.78e-05	Microarray data
GSE93385	K054_mock_infected	K054_ZIKV_infected	up	2.08	5.49e-07	RNA-Seq data
GSE58278	MDDCs_unifected_0h	MDDCs_Dengue_infected_24h	up	2.14	4.09e-02	Microarray data
GSE93385	K048_mock_infected	K048_ZIKV_infected	up	8.23	4.75e-09	RNA-Seq data
GSE97949	uninfected_0h	H7N9_infected_7h	up	1.99	8.25e-15	RNA-Seq data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	up	1.53	2.01e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	2.05	2.92e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	up	2.92	1.67e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	up	2.16	4.28e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	up	3.41	4.36e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	up	2.83	6.10e-03	Microarray data
GSE65699	PRE_mock	PRE_infection_RKAA	up	2.66	4.39e-13	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	down	-2.00	4.05e-02	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_24h	HTBE_H1N1_MOI5_infected_24h	up	1.94	1.46e-04	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	up	4.64	5.64e-07	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	up	3.84	2.61e-11	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-1.60	1.29e-17	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-1.77	6.44e-20	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-1.74	4.59e-25	RNA-Seq data
GSE8961	Mock_infection	HMPV_infection_48h	up	1.88	2.16e-02	Microarray data
GSE8961	Mock_infection	HMPV_infection_72h	up	2.34	7.66e-06	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_12h	up	2.25	2.05e-02	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_24h	up	1.88	1.04e-02	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000105499
Gene description:	Phospholipase A2 group IVC
Chromosome:	19
Position	48047843-48110817
Protein class:	Enzymes, Predicted intracellular proteins, RAS pathway related proteins
Evidence:	Evidence at protein level
Subcellular location:	Cytosol