HVIDB-PPI detail

Q9UJF2 (RASAL2)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: NGAP_HUMAN

UniProtID: Q9UJF2

Gene name(s): RASAL2;NGAP

Protein name: Ras GTPase-activating protein nGAP

Gene ID: 9462

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q9UJF2-P27958	biogrid,HPIDB	18985028	affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	yes (score 0.003).	Show
Machine learning evidence:	yes (score 0.131).

Combined Score: 0.110

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
5233	TNF-alpha/NF-kappa B signaling complex 5	25	0.08 (2/25)	14743216	CORUM	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE75699	HNBE_control_0h	HNBE_infected_8h	up	1.74	1.60e-02	RNA-Seq data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-1.60	1.57e-02	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-1.94	7.42e-04	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-2.08	6.49e-05	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	2.17	5.02e-05	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	1.61	5.93e-03	Microarray data
GSE43794	NPCs_jCV_infection_0h	NPCs_jCV_infection_30d	up	1.56	2.22e-07	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	up	1.83	5.44e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-2.34	5.91e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-1.81	1.54e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	up	2.36	6.11e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	up	1.70	1.83e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	2.41	1.47e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	up	2.53	1.99e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	up	1.96	1.19e-02	Microarray data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	up	1.76	8.93e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	up	3.02	1.31e-02	Microarray data
GSE99389	CD4+_mock_infected_1d	LPS_infected_1d	down	-2.09	1.32e-08	RNA-Seq data
GSE99389	CD4+_mock_infected_4d	LPS_infected_4d	down	-2.00	2.04e-05	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-1.75	1.05e-15	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-1.78	4.37e-16	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	down	-1.72	9.17e-03	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-2.27	4.74e-41	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	down	-2.88	1.02e-76	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-3.05	1.09e-84	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-2.45	1.88e-26	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-2.73	2.91e-47	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-2.73	4.33e-31	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000075391
Gene description:	RAS protein activator like 2
Chromosome:	1
Position	178094141-178484147
Protein class:	Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Evidence:	Evidence at protein level
Subcellular location:	Plasma membrane, Focal adhesion sites