HVIDB-PPI detail

Q9UHV2 (SERTAD1)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: SRTD1_HUMAN

UniProtID: Q9UHV2

Gene name(s): SERTAD1;SEI1;TRIPBR1

Protein name: SERTA domain-containing protein 1

Gene ID: 29950

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q9UHV2-P27958-PRO_0000037566	HPIDB	23487458	protein array

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	yes (score 0.006).	Show
Machine learning evidence:	yes (score 0.772).

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
5107	p34(SEI-1)-CDK4-CyclinD2 complex	3	0.33 (1/3)	15065884	CORUM	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE101760	control_infected	PR8_NS1_infected	up	3.43	1.89e-14	RNA-Seq data
GSE101760	mock_infected	PR8_NS1_infected	up	3.18	6.56e-12	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	up	1.88	4.24e-03	RNA-Seq data
GSE78711-GPL15520	NPC_mock_infected	NPC_Zika_infected	up	1.67	4.91e-03	RNA-Seq data
GSE28166	mock_infected_24h	VN1203_infected_24h	up	2.19	1.06e-04	Microarray data
GSE30723	AMs_control_24h	AMs_PR8_24h	up	2.08	8.85e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-1.69	5.96e-05	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	2.42	2.34e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	3.10	2.42e-08	Microarray data
GSE85493	MeWo_uninfected_36h	MeWo_Y920F_infected_36h	up	1.72	2.41e-03	RNA-Seq data
GSE85493	MeWo_uninfected_36h	MeWo_Y881-920F_infected_36h	up	1.53	2.09e-02	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	4.14	1.14e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	up	2.92	1.44e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	up	1.87	1.11e-02	Microarray data
GSE65699	PRE_mock	PRE_infection_RKAA	up	1.65	1.21e-09	Microarray data
GSE87750-GPL16791	hNCC_mock_infected	hNCC_ZIKV-PRVABC59_infected	up	1.81	9.62e-03	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	1.62	8.71e-18	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-3.38	6.60e-40	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	down	-3.22	6.20e-52	RNA-Seq data
GSE8961	Mock_infection	HMPV_infection_72h	up	1.52	3.62e-03	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000197019
Gene description:	SERTA domain containing 1
Chromosome:	19
Position	40421592-40426025
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm, Golgi apparatus