Q9UHD2 (TBK1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: TBK1_HUMAN

UniProtID: Q9UHD2

Gene name(s): TBK1;NAK

Protein name: Serine/threonine-protein kinase TBK1

Gene ID: 29110

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q9UHD2-P27958PHISTO15841462anti tag coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: yes (score 0.036). Show
Machine learning evidence: yes (score 0.157).
Combined Score: 0.431


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
5212Kinase maturation complex 280.50 (4/8)14743216CORUMView
5286TNF-alpha/NF-kappa B signaling complex 10100.30 (3/10)14743216CORUMView
7405TMEM173-TBK1 complex21.00 (2/2)29547894CORUMView
606Kinase maturation complex 240.25 (1/4)NAhu.MAPView
1328Kinase maturation complex 250.20 (1/5)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE61141non-asthmatic_Vehiclenon-asthmatic_HRV16up1.663.15e-02RNA-Seq data
GSE27702control_macrophagesFPV-infected_macrophagesdown-2.241.89e-03Microarray data
GSE27702control_macrophagesH5N1-infected_macrophagesdown-2.162.67e-03Microarray data
GSE31524H1N1_Mock_infection_10hH1N1_infection_10hdown-2.389.62e-06Microarray data
GSE46041iPS-derived_neurons_uninfectediPS-derived_neurons_HSV-1-infectedup1.763.73e-04Microarray data
GSE65574MCL001_mock_0hMCL001_RFP-MERS_0hdown-3.146.61e-03Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-2.112.73e-03Microarray data
GSE65574MCL001_mock_12hMCL001_icMERS_12hdown-2.232.76e-02Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-2.515.56e-03Microarray data
GSE65574MCL001_mock_24hMCL001_d3-5-MERS_24hup1.937.20e-04Microarray data
GSE65574MCL001_mock_24hMCL001_d4B-MERS_24hup1.541.82e-03Microarray data
GSE65574MCL001_mock_7hMCL001_RFP-MERS_7hdown-3.165.66e-04Microarray data

Human tissue specific expression (TPM)

Small intestine: 16.0 Liver: 9.8 Gallbladder: 22.0 Duodenum: 16.7 Rectum: 12.5 Tonsil: 14.4 Stomach: 12.5 Salivary glanda: 4.6 Adipose tissue: 13.8 Lung: 20.3 Lymph node: 21.2 Pancreas: 1.5 Kidney: 13.7 Colon: 11.2 Appendix: 20.3 Smooth musle: 17.9 Breast: 17.4 Parathyroid gland: 18.1 Esophagus: 13.9 Heart muscle: 6.6 Spleen: 24.2 Skeletal muscle: 3.3 Bone marrow: 21.5 Skin: 12.3 Urinary bladder: 18.2 Cervix, uterine: 15.5 Endometrium: 21.8 Ovary: 14.2 Fallopian tube: 14.5 Seminal vesicle: 15.1 Prostate: 21.1 Epididymis: 15.7 Testis: 49.3 Placenta: 23.8 Thyroid gland: 18.2 Cerebral cortex: 21.8 Adrenal gland: 21.1
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000183735
Gene description:TANK binding kinase 1
Chromosome:12
Position64451880-64502108
Protein class:Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm