Q9UFF9 (CNOT8)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: CNOT8_HUMAN

UniProtID: Q9UFF9

Gene name(s): CNOT8;CALIF;POP2

Protein name: CCR4-NOT transcription complex subunit 8

Gene ID: 9337

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q9UFF9-P27958-PRO_0000037566HPIDB23487458protein array

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.696). Show
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.703).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
7215CCR4-NOT-CNOT8-CNOT6 complex90.11 (1/9)19558367CORUMView
7216CCR4-NOT-CNOT8-CNOT6L complex90.11 (1/9)19558367CORUMView
1013CCR4-NOT complex100.10 (1/10)NAhu.MAPView
1360CCR4-NOT complex150.07 (1/15)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE27702control_macrophagesFPV-infected_macrophagesdown-1.895.65e-03Microarray data
GSE27702control_macrophagesH5N1-infected_macrophagesdown-1.914.44e-03Microarray data
GSE31524H1N1_Mock_infection_10hH1N1_infection_10hdown-1.686.28e-05Microarray data
GSE32140-GPL6480mock_for_RSV_2hRSV_infectiondown-1.748.50e-06Microarray data
GSE32155HTB-3_unifectedHTB-174_infectedup2.211.93e-05Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_NL219_pCalu3_24hdown-3.791.32e-04Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hdown-2.833.90e-06Microarray data
GSE65574MCL001_mock_0hMCL001_RFP-MERS_0hdown-2.311.11e-02Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-2.485.82e-04Microarray data
GSE65574MCL001_mock_12hMCL001_icMERS_12hdown-2.387.88e-03Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-2.601.05e-03Microarray data
GSE65574MCL001_mock_24hMCL001_icMERS_24hdown-2.004.42e-02Microarray data
GSE65574MCL001_mock_7hMCL001_RFP-MERS_7hdown-2.201.03e-03Microarray data
GSE97672-GPL16791MDM-520_H5N1_MOI0_12hMDM-520_H5N1_MOI2_12hdown-2.771.98e-54RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hdown-1.781.08e-05RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-2.103.62e-26RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 39.9 Liver: 14.6 Gallbladder: 46.0 Duodenum: 32.7 Rectum: 49.8 Tonsil: 47.3 Stomach: 28.1 Salivary glanda: 11.6 Adipose tissue: 45.0 Lung: 62.9 Lymph node: 65.8 Pancreas: 4.7 Kidney: 29.9 Colon: 40.0 Appendix: 50.5 Smooth musle: 45.9 Breast: 55.7 Parathyroid gland: 51.7 Esophagus: 28.1 Heart muscle: 15.5 Spleen: 67.4 Skeletal muscle: 5.8 Bone marrow: 74.6 Skin: 33.2 Urinary bladder: 41.1 Cervix, uterine: 61.7 Endometrium: 55.0 Ovary: 36.6 Fallopian tube: 46.7 Seminal vesicle: 38.3 Prostate: 45.4 Epididymis: 43.8 Testis: 61.4 Placenta: 58.7 Thyroid gland: 58.0 Cerebral cortex: 45.0 Adrenal gland: 47.4
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000155508
Gene description:CCR4-NOT transcription complex subunit 8
Chromosome:5
Position154857553-154876793
Protein class:Enzymes, Plasma proteins, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location: