Q9HCE7 (SMURF1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: SMUF1_HUMAN

UniProtID: Q9HCE7

Gene name(s): SMURF1;KIAA1625

Protein name: E3 ubiquitin-protein ligase SMURF1

Gene ID: 57154

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q9HCE7-P27958biogrid,HPIDB23781096two hybrid

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.057).
Combined Score: 0.031


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1783Ubiquitin E3 ligase (SMAD7, SMURF1) - TGFBR130.67 (2/3)11278251CORUMView
2996Ubiquitin E3 ligase (SMAD7, SMURF1)21.00 (2/2)11278251CORUMView
2997Ubiquitin E3 ligase (SMAD7-SMURF1) - TGF(beta)40.50 (2/4)11278251CORUMView
1142SMAD7-SMURF2 complex90.33 (3/9)NAhu.MAPView
4293SMURF1-EPN2-EPN330.33 (1/3)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE101760control_infectedPR8_NS1_infectedup1.881.29e-03RNA-Seq data
GSE102481mock_infected_18hRVFV_MP12_infected_18hup1.738.07e-14RNA-Seq data
GSE102924controlZIKV-Brazil_Dakar_strainsup1.563.72e-08RNA-Seq data
GSE32155HTB-3_unifectedHTB-174_infectedup1.636.41e-05Microarray data
GSE32155HTB-4_unifectedHTB-174_infectedup2.084.35e-05Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_NL219_pCalu3_24hdown-3.802.51e-03Microarray data
GSE65574MCL001_mock_12hMCL001_d3-5-MERS_12hup2.035.08e-03Microarray data
GSE65574MCL001_mock_24hMCL001_d3-5-MERS_24hup3.593.12e-03Microarray data
GSE65574MCL001_mock_24hMCL001_d4B-MERS_24hup3.051.35e-03Microarray data
GSE65574MCL001_mock_24hMCL001_dNSP16-MERS_24hup3.466.12e-03Microarray data
GSE65574MCL001_mock_24hMCL001_RFP-MERS_24hup2.902.68e-02Microarray data

Human tissue specific expression (TPM)

Small intestine: 4.8 Liver: 2.1 Gallbladder: 9.0 Duodenum: 4.3 Rectum: 5.1 Tonsil: 3.6 Stomach: 8.8 Salivary glanda: 1.8 Adipose tissue: 6.9 Lung: 9.7 Lymph node: 4.7 Pancreas: 1.6 Kidney: 3.8 Colon: 4.4 Appendix: 6.3 Smooth musle: 6.3 Breast: 4.5 Parathyroid gland: 6.0 Esophagus: 9.0 Heart muscle: 2.3 Spleen: 5.4 Skeletal muscle: 1.6 Bone marrow: 8.6 Skin: 9.3 Urinary bladder: 5.6 Cervix, uterine: 7.2 Endometrium: 7.5 Ovary: 9.0 Fallopian tube: 6.7 Seminal vesicle: 5.6 Prostate: 6.2 Epididymis: 2.7 Testis: 22.9 Placenta: 8.9 Thyroid gland: 4.6 Cerebral cortex: 8.0 Adrenal gland: 6.4
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000198742
Gene description:SMAD specific E3 ubiquitin protein ligase 1
Chromosome:7
Position99027438-99144100
Protein class:Enzymes, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location: