Human protein: SMUF2_HUMAN
UniProtID: Q9HAU4
Gene name(s): SMURF2
Protein name: E3 ubiquitin-protein ligase SMURF2
Gene ID: 64750
HDF/HRF: NA
Virus protein: POLG_HCVH (HCV-H)
UniProtID: P27958
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| Q9HAU4-P27958 | biogrid,HPIDB | 23781096 | two hybrid |
| Interolog evidence: | none/insignificant. |
| DDI evidence: | none/insignificant. |
| Machine learning evidence: | yes (score 0.131). |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 1777 | Ubiquitin E3 ligase (SMURF2, SMAD7) - TGF(beta) | 4 | 0.50 (2/4) | 11163210 | CORUM | View |
| 1784 | RNF11-SMURF2-STAMBP complex | 3 | 0.33 (1/3) | 14755250 | CORUM | View |
| 2992 | Ubiquitin E3 ligase (SMAD7, SMURF2) | 2 | 1.00 (2/2) | 11163210 | CORUM | View |
| 3972 | Ubiquitin E3 ligase (SMURF2, SMAD3) - SnoN complex, TGF(beta)-dependent | 3 | 0.67 (2/3) | 11389444 | CORUM | View |
| 144 | SMAD7-SMURF2 complex | 4 | 0.25 (1/4) | NA | hu.MAP | View |
| 772 | SMAD7-SMURF2 complex | 4 | 0.25 (1/4) | NA | hu.MAP | View |
| 1142 | SMAD7-SMURF2 complex | 9 | 0.33 (3/9) | NA | hu.MAP | View |
| 1247 | SMAD7-SMURF2 complex | 4 | 0.50 (2/4) | NA | hu.MAP | View |
| 4211 | SMAD7-SMURF2 complex | 4 | 0.25 (1/4) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE27702 | control_macrophages | H5N1-infected_macrophages | down | -1.66 | 6.13e-03 | Microarray data |
| GSE28166 | mock_infected_24h | VN1203_infected_24h | down | -1.59 | 1.28e-02 | Microarray data |
| GSE31524 | H1N1_Mock_infection_10h | H1N1_infection_10h | down | -2.10 | 5.59e-06 | Microarray data |
| GSE32155 | HTB-3_unifected | HTB-174_infected | up | 1.92 | 6.18e-05 | Microarray data |
| GSE32155 | HTB-4_unifected | HTB-174_infected | up | 1.86 | 3.74e-04 | Microarray data |
| GSE49628 | Bcells_Quiescent | Bcells_Activation | down | -2.03 | 2.43e-04 | Microarray data |
| GSE49628 | Bcells_Quiescent | Bcells_EBV_transformed | down | -2.14 | 4.42e-04 | Microarray data |
| GSE49840 | Hu_Mock_pCalu3_24h | Hu_Anhui01_pCalu3_24h | up | 1.77 | 1.45e-03 | Microarray data |
| GSE50938 | extracted_total_RNA_mock-infected_NHDFs | extracted_total_RNA_HCMV-infected_HNDFs_48h_post-infection | down | -3.48 | 9.05e-06 | Microarray data |
| GSE50938 | polysomal_RNA_mock-infected_NHDFs | polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection | down | -2.92 | 1.10e-03 | Microarray data |
| GSE59226 | Control | Virus_infection | down | -2.77 | 1.19e-04 | Microarray data |
| GSE65123 | healthy_seronegative_control | HCV_infected | down | -3.61 | 4.88e-02 | Microarray data |
| GSE97672-GPL16791 | MDM-513_H5N1_MOI0_06h | MDM-513_H5N1_MOI2_06h | down | -1.56 | 7.48e-11 | RNA-Seq data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
| Ensembl ID: | ENSG00000108854 |
| Gene description: | SMAD specific E3 ubiquitin protein ligase 2 |
| Chromosome: | 17 |
| Position | 64542295-64662068 |
| Protein class: | Enzymes, Predicted intracellular proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nuclear speckles |