Q9H9L4 (KANSL2)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: KANL2_HUMAN

UniProtID: Q9H9L4

Gene name(s): KANSL2;C12orf41;NSL2

Protein name: KAT8 regulatory NSL complex subunit 2

Gene ID: 54934

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q9H9L4-P27958-PRO_0000037566HPIDB23487458protein array

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.211).
Combined Score: 0.289


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
7221NSL complex90.22 (2/9)20018852CORUMView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE13637HUVEC_controlFPV-infected_HUVECdown-1.828.45e-04Microarray data
GSE27702control_macrophagesFPV-infected_macrophagesdown-1.811.06e-02Microarray data
GSE27702control_macrophagesH5N1-infected_macrophagesdown-1.591.22e-02Microarray data
GSE28166mock_infected_18hVN1203_infected_18hup2.096.70e-04Microarray data
GSE28166mock_infected_24hVN1203_infected_24hup2.985.63e-05Microarray data
GSE31524H1N1_Mock_infection_10hH1N1_infection_10hdown-2.161.13e-05Microarray data
GSE45042ELC001_mock_infected_24hECL001_EMC_infected_24hup1.881.39e-04Microarray data
GSE46041iPS-derived_neurons_uninfectediPS-derived_neurons_HSV-1-infectedup2.121.73e-04Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_Anhui01_pCalu3_24hup1.766.32e-07Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hup1.642.24e-06Microarray data
GSE65574MCL001_mock_24hMCL001_d3-5-MERS_24hup1.654.58e-04Microarray data
GSE97672-GPL16791MDM-418_H3N2_MOI0_06hMDM-418_H3N2_MOI2_06hdown-1.565.95e-07RNA-Seq data
GSE97672-GPL16791MDM-513_H5N1_MOI0_06hMDM-513_H5N1_MOI2_06hdown-2.186.74e-14RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_06hMDM-520_H5N1_MOI2_06hdown-1.931.75e-13RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 8.7 Liver: 5.4 Gallbladder: 14.3 Duodenum: 9.3 Rectum: 12.4 Tonsil: 14.6 Stomach: 8.9 Salivary glanda: 4.3 Adipose tissue: 9.5 Lung: 15.2 Lymph node: 18.9 Pancreas: 2.0 Kidney: 14.8 Colon: 10.2 Appendix: 13.1 Smooth musle: 17.2 Breast: 18.2 Parathyroid gland: 16.6 Esophagus: 13.1 Heart muscle: 8.9 Spleen: 15.5 Skeletal muscle: 12.8 Bone marrow: 31.9 Skin: 10.9 Urinary bladder: 11.7 Cervix, uterine: 17.2 Endometrium: 19.3 Ovary: 18.2 Fallopian tube: 18.3 Seminal vesicle: 13.9 Prostate: 16.4 Epididymis: 17.0 Testis: 29.6 Placenta: 20.0 Thyroid gland: 19.5 Cerebral cortex: 14.4 Adrenal gland: 12.0
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000139620
Gene description:KAT8 regulatory NSL complex subunit 2
Chromosome:12
Position48653401-48682238
Protein class:Predicted intracellular proteins, Predicted secreted proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm, Plasma membrane, Cytosol