HVIDB-PPI detail

Q9H8X2 (IPPK)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: IPPK_HUMAN

UniProtID: Q9H8X2

Gene name(s): IPPK;C9orf12

Protein name: Inositol-pentakisphosphate 2-kinase

Gene ID: 64768

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q9H8X2-P27958-PRO_0000037566	HPIDB	23487458	protein array

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	yes (score 0.020).	Show
Machine learning evidence:	yes (score 0.698).

Combined Score: 1.000

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE79968	IMR90_GFP_32h	IMR90_MCPyV_ST_32h	up	3.23	2.55e-03	RNA-Seq data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-3.59	1.72e-04	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-5.15	1.37e-03	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-2.27	2.46e-03	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	1.53	2.07e-04	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	1.78	3.40e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-1.72	5.76e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-1.65	4.45e-06	Microarray data
GSE65123	healthy_seronegative_control	HCV_infected	down	-2.36	3.73e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	up	1.55	4.36e-03	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_6h	HTBE_H5N1_MOI5_infected_6h	down	-1.70	6.90e-08	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-2.45	3.92e-15	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.77	2.72e-13	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-2.63	7.86e-11	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-3.62	1.44e-22	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	down	-2.57	3.24e-17	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-2.32	2.95e-17	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-1.92	3.29e-11	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-2.63	1.14e-11	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-2.60	8.66e-11	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000127080
Gene description:	Inositol-pentakisphosphate 2-kinase
Chromosome:	9
Position	92613184-92670265
Protein class:	Enzymes, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Cytosol