Q9H0F6 (SHARPIN)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
Networks viewer (Cytoscape.js) and color tagging feature require Firefox or Chrome browsers to work properly

Human protein: SHRPN_HUMAN

UniProtID: Q9H0F6

Gene name(s): SHARPIN;SIPL1;PSEC0216

Protein name: Sharpin

Gene ID: 81858

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q9H0F6-P27958biogrid,HPIDB26577923affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: yes (score 0.061). Show
Machine learning evidence: yes (score 0.122).
Combined Score: 0.548


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
6178LUBAC complex31.00 (3/3)21455180CORUMView
4562LUBAC complex40.50 (2/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE65574MCL001_mock_12hMCL001_d3-5-MERS_12hdown-1.671.61e-03Microarray data

Human tissue specific expression (TPM)

Small intestine: 14.8 Liver: 6.9 Gallbladder: 21.7 Duodenum: 16.8 Rectum: 11.3 Tonsil: 9.9 Stomach: 15.4 Salivary glanda: 10.8 Adipose tissue: 20.2 Lung: 21.9 Lymph node: 17.2 Pancreas: 4.2 Kidney: 11.2 Colon: 15.2 Appendix: 16.5 Smooth musle: 18.8 Breast: 11.0 Parathyroid gland: 25.7 Esophagus: 17.8 Heart muscle: 14.1 Spleen: 22.5 Skeletal muscle: 14.1 Bone marrow: 13.9 Skin: 23.3 Urinary bladder: 16.6 Cervix, uterine: 22.8 Endometrium: 20.2 Ovary: 19.9 Fallopian tube: 28.9 Seminal vesicle: 22.0 Prostate: 20.4 Epididymis: 10.7 Testis: 66.1 Placenta: 18.3 Thyroid gland: 20.5 Cerebral cortex: 15.8 Adrenal gland: 23.8
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000179526
Gene description:SHANK associated RH domain interactor
Chromosome:8
Position144098633-144108124
Protein class:Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Nucleus, Cytosol