Q9BYW2 (SETD2)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: SETD2_HUMAN

UniProtID: Q9BYW2

Gene name(s): SETD2;HIF1;HYPB;KIAA1732;KMT3A;SET2;HSPC069

Protein name: Histone-lysine N-methyltransferase SETD2

Gene ID: 29072

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q9BYW2-P27958biogrid,HPIDB18985028two hybrid

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.257).
Combined Score: 0.466


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1796AURKA-HDAC6 cilia-disassembly complex70.29 (2/7)NAhu.MAPView
3535AURKA-HDAC6 cilia-disassembly complex40.50 (2/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE102481mock_infected_18hRVFV_MP12_infected_18hup1.573.27e-11RNA-Seq data
GSE28166mock_infected_24hVN1203_infected_24hup1.852.52e-04Microarray data
GSE46041iPS-derived_neurons_uninfectediPS-derived_neurons_HSV-1-infectedup1.633.73e-04Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_NL219_pCalu3_24hdown-3.871.51e-04Microarray data
GSE65123healthy_seronegative_controlHCV_infecteddown-4.813.73e-02Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-1.664.51e-05Microarray data
GSE65574MCL001_mock_24hMCL001_d3-5-MERS_24hup1.984.93e-04Microarray data
GSE65574MCL001_mock_24hMCL001_d4B-MERS_24hup1.924.60e-03Microarray data
GSE65574MCL001_mock_24hMCL001_dNSP16-MERS_24hup2.347.35e-03Microarray data
GSE65574MCL001_mock_24hMCL001_RFP-MERS_24hup2.871.22e-02Microarray data

Human tissue specific expression (TPM)

Small intestine: 11.3 Liver: 5.3 Gallbladder: 12.8 Duodenum: 9.5 Rectum: 11.5 Tonsil: 11.9 Stomach: 9.6 Salivary glanda: 3.5 Adipose tissue: 10.6 Lung: 13.0 Lymph node: 14.8 Pancreas: 2.7 Kidney: 11.7 Colon: 9.1 Appendix: 13.3 Smooth musle: 16.8 Breast: 11.5 Parathyroid gland: 31.8 Esophagus: 10.4 Heart muscle: 4.3 Spleen: 14.1 Skeletal muscle: 2.4 Bone marrow: 14.3 Skin: 9.5 Urinary bladder: 10.8 Cervix, uterine: 18.4 Endometrium: 20.5 Ovary: 18.1 Fallopian tube: 17.0 Seminal vesicle: 13.0 Prostate: 15.8 Epididymis: 4.9 Testis: 24.3 Placenta: 15.3 Thyroid gland: 25.4 Cerebral cortex: 11.9 Adrenal gland: 8.2
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000181555
Gene description:SET domain containing 2
Chromosome:3
Position47016429-47163967
Protein class:Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Nuclear speckles, Cytosol