HVIDB-PPI detail

Q9BUV0 (RSRP1)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: RSRP1_HUMAN

UniProtID: Q9BUV0

Gene name(s): RSRP1;C1orf63;HT033;NPD014

Protein name: Arginine/serine-rich protein 1

Gene ID: 57035

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q9BUV0-P27958-PRO_0000037566	HPIDB	23487458	protein array

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.240).

Combined Score: 0.396

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
257	PA28gamma complex	7	0.29 (2/7)	NA	hu.MAP	View
1241	PA28gamma complex	6	0.33 (2/6)	NA	hu.MAP	View
4055	PA28gamma complex	4	0.50 (2/4)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE101760	control_infected	PR8_NS1_infected	up	1.97	8.95e-03	RNA-Seq data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-2.44	1.51e-02	Microarray data
GSE27702	control_macrophages	H5N1-infected_macrophages	down	-1.63	5.07e-03	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	up	1.59	1.61e-03	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	up	3.04	3.93e-05	Microarray data
GSE31524	H1N1_Mock_infection_10h	H1N1_infection_10h	down	-1.69	1.38e-04	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	down	-1.62	1.12e-04	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	down	-1.68	7.88e-03	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-1.53	1.22e-04	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	3.03	1.36e-04	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	up	2.17	6.78e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	2.15	6.67e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	up	3.01	2.00e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	2.61	1.14e-07	Microarray data
GSE59226	Control	Virus_infection	down	-1.59	2.17e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	2.54	2.02e-03	Microarray data
GSE99298	mock_infected_0h	hRSV_WT_infected_96h	up	1.94	1.39e-03	RNA-Seq data
GSE99298	mock_infected_0h	hRSV_NS1_L132A_L133A_infected_96h	up	2.17	3.65e-03	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	up	1.79	7.16e-10	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_4hrs	down	-1.91	2.19e-11	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_8hrs	down	-1.58	1.55e-10	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_4hrs	down	-1.91	3.37e-11	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_4hrs	down	-1.87	4.53e-11	Microarray data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	down	-1.58	7.49e-06	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_8hrs	down	-1.53	2.10e-10	Microarray data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	1.55	3.33e-08	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000117616
Gene description:	Arginine and serine rich protein 1
Chromosome:	1
Position	25242237-25338213
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm