Q99986 (VRK1)
Homo sapiensP27958-PRO_0000037566 (NA)
Hepatitis C virus genotype 1a (isolate H) (HCV)Human protein: VRK1_HUMAN
UniProtID: Q99986
Gene name(s): VRK1
Protein name: Serine/threonine-protein kinase VRK1
Gene ID: 7443
HDF/HRF: NA
Virus protein: Core protein p21(POLG_HCVH) (HCV-H)
UniProtID: P27958-PRO_0000037566
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| Q99986-P27958-PRO_0000037566 | HPIDB | 23487458 | protein array |
| Interolog evidence: | yes (score 0.696). | Show |
| DDI evidence: | none/insignificant. | |
| Machine learning evidence: | yes (score 0.735). |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 7101 | AURKB-VRK1 complex | 2 | 0.50 (1/2) | 29340707 | CORUM | View |
| 7102 | SOX2-VRK1 complex | 2 | 0.50 (1/2) | 27334688 | CORUM | View |
| 7103 | NBS1-VRK1 complex | 2 | 0.50 (1/2) | 26869104 | CORUM | View |
| 7104 | NBS1u2013RNF8-VRK1 complex | 3 | 0.33 (1/3) | 26869104 | CORUM | View |
| 3528 | VRK1-CYP1A1 | 2 | 0.50 (1/2) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE32140-GPL6480 | mock_for_RSV_2h | RSV_infection | down | -1.76 | 4.00e-06 | Microarray data |
| GSE45042 | ELC001_mock_infected_24h | ECL001_EMC_infected_24h | up | 1.54 | 7.46e-05 | Microarray data |
| GSE92496 | control_vector | HPV16_E6-E7_vector | up | 1.55 | 7.26e-05 | RNA-Seq data |
| GSE59226 | Control | Virus_infection | down | -1.87 | 1.63e-04 | Microarray data |
| GSE97949 | uninfected_0h | H7N9_infected_7h | down | -1.80 | 1.25e-13 | RNA-Seq data |
| GSE65574 | MCL001_mock_24h | MCL001_d3-5-MERS_24h | down | -2.28 | 3.49e-04 | Microarray data |
| GSE65574 | MCL001_mock_24h | MCL001_d4B-MERS_24h | down | -1.53 | 2.15e-03 | Microarray data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
| Ensembl ID: | ENSG00000100749 |
| Gene description: | Vaccinia related kinase 1 |
| Chromosome: | 14 |
| Position | 96797304-96931722 |
| Protein class: | Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Nucleus, Cytosol |