HVIDB-PPI detail

Q99878 (H2AC14)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: H2A1J_HUMAN

UniProtID: Q99878

Gene name(s): H2AC14;H2AFE;HIST1H2AJ

Protein name: Histone H2A type 1-J

Gene ID: 8331

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q99878-P27958	biogrid,HPIDB	22810585	affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 1.000).	Show
DDI evidence:	yes (score 0.081).	Show
Machine learning evidence:	yes (score 0.147).

Combined Score: 0.999

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-3.64	3.80e-03	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	down	-1.86	3.84e-02	RNA-Seq data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-1.76	5.97e-04	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	up	2.11	1.38e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-1.69	8.75e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	down	-1.53	2.28e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-1.75	4.38e-06	Microarray data
GSE53103	Namalwa_shscr	Namalwa_shscr_+SV_6h	down	-2.17	6.21e-07	Microarray data
GSE92496	control_vector	HPV16_E6-E7_vector	up	2.03	1.22e-09	RNA-Seq data
GSE93385	K048_mock_infected	K048_ZIKV_infected	down	-2.61	1.38e-29	RNA-Seq data
GSE65574	MCL001_mock_0h	MCL001_d3-5-MERS_0h	down	-2.23	4.16e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-4.00	2.34e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-3.34	5.66e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-2.48	5.59e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-1.94	1.48e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	down	-2.42	5.49e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	down	-2.22	8.32e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-2.47	8.57e-03	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-1.56	3.08e-02	Microarray data
GSE87750-GPL16791	hNCC_mock_infected	hNCC_ZIKV-PRVABC59_infected	down	-2.52	2.73e-02	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-2.14	4.80e-17	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	down	-1.51	9.53e-05	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-3.00	1.60e-32	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	down	-2.89	9.40e-28	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-1.90	1.37e-06	RNA-Seq data
GSE93861	healthy_blood_control	Ebola_infection	up	3.55	4.56e-17	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
bone marrow	6.4

Ensembl ID:	ENSG00000276368
Gene description:	Histone cluster 1 H2A family member j
Chromosome:	6
Position	27814354-27814740
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location: