HVIDB-PPI detail

Q99836 (MYD88)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: MYD88_HUMAN

UniProtID: Q99836

Gene name(s): MYD88

Protein name: Myeloid differentiation primary response protein MyD88

Gene ID: 4615

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q99836-P27958	PHISTO	17567694	anti tag coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.093).

Combined Score: 0.055

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1638	MYD88-SPOP	2	0.50 (1/2)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE101760	control_infected	PR8_NS1_infected	up	2.58	4.59e-02	RNA-Seq data
GSE61141	non-asthmatic_Vehicle	non-asthmatic_HRV16	up	1.93	1.80e-06	RNA-Seq data
GSE75699	HNBE_control_0h	HNBE_infected_24h	up	2.17	1.06e-08	RNA-Seq data
GSE84285	A549_mock_infected_36h	A549_Dengue_virus_infected_36h	down	-1.57	6.05e-52	RNA-Seq data
GSE13637	HUVEC_control	PR8-infected_HUVEC	up	1.76	4.98e-06	Microarray data
GSE13637	HUVEC_control	PR8-infected_IKK2kd-transfected_HUVEC	up	1.75	2.41e-05	Microarray data
GSE13637	HUVEC_control	PR8-infected_pEGZ-transfected_HUVEC	up	1.93	4.08e-06	Microarray data
GSE15810	hMSCs_mock-transduced	hMSCs_BV-transduced	up	2.77	1.27e-03	Microarray data
GSE24238	Mock_24h	HCMV_24h	up	1.92	6.65e-03	Microarray data
GSE30719	uninfected_primary_RPE	WNV_infected_primary_RPE_24h	up	1.82	1.41e-04	Microarray data
GSE30723	ATII_control_24h	ATII_PR8_24h	up	2.32	1.97e-04	Microarray data
GSE31524	H5N2-F189_Mock_infection	H5N2-F189_infection_10h	up	1.93	5.71e-07	Microarray data
GSE31524	H5N2-F59_Mock_infection	H5N2-F59_infection_10h	up	2.17	3.69e-07	Microarray data
GSE31524	H9N2_Mock_infection	H9N2_infection_10h	up	1.76	2.34e-07	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	1.71	2.60e-04	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	up	1.98	3.16e-05	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	2.35	4.52e-05	Microarray data
GSE32140-GPL6947	mock_for_RSV_2h	RSV_infection_2h	up	1.51	8.58e-03	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	2.88	1.24e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	up	2.11	5.78e-04	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	1.60	1.84e-03	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	down	-1.54	2.74e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Pan99_pCalu3_12h	up	2.07	9.62e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	2.23	1.42e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	1.50	4.54e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	1.69	1.80e-06	Microarray data
GSE54293	NCI-H1666_mock	NCI-H1666_infected	up	1.60	1.38e-06	Microarray data
GSE92496	control_vector	HPV16_E6-E7_vector	down	-2.66	2.95e-15	RNA-Seq data
GSE59226	Control	Virus_infection	up	1.66	2.15e-04	Microarray data
GSE65123	healthy_seronegative_control	HCV_infected	down	-4.37	4.21e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-2.25	6.30e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-1.59	6.83e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	2.62	1.71e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	up	1.67	1.62e-02	Microarray data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	2.26	2.44e-08	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	up	1.82	6.94e-03	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-1.53	1.11e-02	Microarray data
GSE65699	PRE_mock	PRE_infection_RKAA	up	1.92	1.98e-11	Microarray data
GSE65699	PRE_mock	PRE_infection_WT	up	2.14	1.49e-12	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_16h	up	1.54	8.77e-04	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	1.83	1.13e-03	Microarray data
GSE99298	mock_infected_0h	hRSV_NS1_1_118_infected_96h	up	4.94	8.00e-04	RNA-Seq data
GSE99298	mock_infected_0h	hRSV_NS1_L132A_L133A_infected_96h	up	5.64	1.05e-03	RNA-Seq data
GSE99298	mock_infected_0h	hRSV_NS1_Y125A_infected_96h	up	5.54	9.71e-04	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_3h	HTBE_H3N2_MOI5_infected_3h	up	1.79	3.93e-07	RNA-Seq data
GSE71766	BEAS-2B_control_24hrs	BEAS-2B_InfluenzaVirus_24hrs	up	1.57	2.12e-10	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_12h	HTBE_H1N1_MOI5_infected_12h	up	2.12	5.32e-29	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_12h	HTBE_H3N2_MOI5_infected_12h	up	3.58	7.16e-05	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_06h	MDM-315_H1N1_MOI2_06h	up	2.43	4.02e-02	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	up	2.07	2.24e-07	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	2.39	7.29e-10	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	up	1.73	3.34e-06	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	2.20	1.85e-02	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_24hrs	up	1.54	4.05e-10	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_03h	MDM-418_H3N2_MOI2_03h	up	3.11	4.60e-05	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_03h	MDM-520_H5N1_MOI2_03h	up	1.92	2.22e-05	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	up	2.56	5.27e-18	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	2.15	2.18e-19	RNA-Seq data
GSE8961	Mock_infection	HMPV_infection_12h	up	1.65	3.63e-04	Microarray data
GSE8961	Mock_infection	HMPV_infection_24h	up	2.05	3.10e-05	Microarray data
GSE8961	Mock_infection	HMPV_infection_48h	up	1.84	1.72e-02	Microarray data
GSE9378	HUVECs_mock-infected_control	HUVECs_DV_infection_48h	up	1.83	2.97e-02	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_6h	up	1.57	7.02e-05	Microarray data
GSE99858	PBMC_control	PBMC_RV16_infection	up	1.61	1.01e-11	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000172936
Gene description:	Myeloid differentiation primary response 88
Chromosome:	3
Position	38138478-38143022
Protein class:	Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Vesicles, Mitochondria, Cytosol