Human protein: VPS35_HUMAN
UniProtID: Q96QK1
Gene name(s): VPS35;MEM3;TCCCTA00141
Protein name: Vacuolar protein sorting-associated protein 35
Gene ID: 55737
HDF/HRF: NA
Virus protein: POLG_HCVH (HCV-H)
UniProtID: P27958
Gene name(s): NA
Protein name: Genome polyprotein
Gene ID: NA
Viral family: Flaviviridae
| Interaction | Source database | PubMed ID | Detection method |
|---|---|---|---|
| Q96QK1-P27958 | PHISTO | 17616579 | Other Methods |
| Interolog evidence: | none/insignificant. | |
| DDI evidence: | yes (score 0.016). | Show |
| Machine learning evidence: | yes (score 0.145). |
Virally targeted human complex
| Complex id | Complex name | Complex size | Target ratio | PudMed ID | Source | Detail |
|---|---|---|---|---|---|---|
| 1059 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) | 5 | 0.20 (1/5) | 11102511 | CORUM | View |
| 1060 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) | 5 | 0.20 (1/5) | 11102511 | CORUM | View |
| 656 | VPS35-VPS29-VPS26A complex | 3 | 0.33 (1/3) | 11102511 | CORUM | View |
| 657 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) | 5 | 0.20 (1/5) | 16732284 | CORUM | View |
| 397 | VPS35-VPS29-VPS26A complex | 11 | 0.09 (1/11) | NA | hu.MAP | View |
| 3924 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) | 5 | 0.20 (1/5) | NA | hu.MAP | View |
Differentially expression condition
| Series | Control | Treatment | Regulation | Log2FC | Adj.P.Val | Data type |
|---|---|---|---|---|---|---|
| GSE30589 | Vero_E6_Mock_infected_15hpi | Vero_E6_SARS-Cov_DeltaE_15hpi | down | -2.21 | 1.21e-06 | Microarray data |
| GSE30589 | Vero_E6_Mock_infected_15hpi | Vero_E6_SARS-Cov_WT_15hpi | down | -2.09 | 1.16e-06 | Microarray data |
| GSE65574 | MCL001_mock_0h | MCL001_RFP-MERS_0h | down | -1.86 | 9.35e-03 | Microarray data |
| GSE65574 | MCL001_mock_12h | MCL001_d4B-MERS_12h | down | -2.11 | 6.71e-05 | Microarray data |
| GSE65574 | MCL001_mock_7h | MCL001_RFP-MERS_7h | down | -2.00 | 6.13e-04 | Microarray data |
| GSE89008 | HTBE_H5N1_MOI0_mock_infected_12h | HTBE_H5N1_MOI5_infected_12h | down | -1.58 | 4.70e-18 | RNA-Seq data |
| GSE89008 | HTBE_H5N1_MOI0_mock_infected_18h | HTBE_H5N1_MOI5_infected_18h | down | -2.24 | 9.60e-42 | RNA-Seq data |
| GSE97672-GPL16791 | MDM-418_H3N2_MOI0_18h | MDM-418_H3N2_MOI2_18h | down | -1.90 | 4.95e-30 | RNA-Seq data |
| GSE97672-GPL16791 | MDM-520_H5N1_MOI0_12h | MDM-520_H5N1_MOI2_12h | down | -1.99 | 1.42e-29 | RNA-Seq data |
| GSE97672-GPL16791 | MDM-520_H5N1_MOI0_18h | MDM-520_H5N1_MOI2_18h | down | -2.57 | 8.16e-51 | RNA-Seq data |
| GSE97672-GPL18573 | MDM-513_H5N1_MOI0_18h | MDM-513_H5N1_MOI2_18h | down | -2.66 | 8.04e-83 | RNA-Seq data |
Human tissue specific expression (TPM)
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
| Ensembl ID: | ENSG00000069329 |
| Gene description: | VPS35, retromer complex component |
| Chromosome: | 16 |
| Position | 46656132-46689518 |
| Protein class: | Disease related genes, Plasma proteins, Predicted intracellular proteins |
| Evidence: | Evidence at protein level |
| Subcellular location: | Endosomes, Lysosomes |