HVIDB-PPI detail

Q96P48 (ARAP1)

Homo sapiens

P27958-PRO_0000037576 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: ARAP1_HUMAN

UniProtID: Q96P48

Gene name(s): ARAP1;CENTD2;KIAA0782

Protein name: Arf-GAP with Rho-GAP domain

Gene ID: 116985

HDF/HRF: NA

Virus protein: Non-structural protein 5A(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037576

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q96P48-P27958-PRO_0000037576	HPIDB	15607035	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.748).	Show
DDI evidence:	yes (score 0.025).	Show
Machine learning evidence:	yes (score 0.659).

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
2441	WIPF3-NCK2-DOK1-ARAP1	4	0.25 (1/4)	NA	hu.MAP	View
3589	TTC28-PIK3AP1-SEMA6A-SHB-DOK1-CBL-WIPF3-ABL2-CASKIN2-ASAP2-NCK2-ARAP1-ASAP1	13	0.08 (1/13)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE101760	mock_infected	PR8_infected	down	-2.49	1.64e-02	RNA-Seq data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-1.78	2.36e-04	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-3.54	1.34e-03	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-3.15	5.46e-05	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	down	-1.61	5.14e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	up	1.84	2.82e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	up	1.69	3.84e-03	Microarray data
GSE99298	mock_infected_0h	hRSV_NS1_1_118_infected_96h	up	20.37	3.68e-04	RNA-Seq data
GSE99298	mock_infected_0h	hRSV_NS1_Y125A_infected_96h	up	8.77	4.49e-05	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-1.89	1.02e-16	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.57	2.51e-29	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-2.49	9.81e-54	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	down	-2.33	5.81e-06	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-2.03	5.15e-39	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-2.81	2.68e-75	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-3.73	1.20e-83	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-3.56	4.07e-143	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-2.66	1.06e-63	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000186635
Gene description:	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Chromosome:	11
Position	72685069-72793599
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm, Vesicles, Plasma membrane, Cytosol