HVIDB-PPI detail

Q96KK5 (HIST1H2AH)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

Networks viewer (Cytoscape.js) and color tagging feature require Firefox or Chrome browsers to work properly

Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: H2A1H_HUMAN

UniProtID: Q96KK5

Gene name(s): HIST1H2AH;HIST1H2AI

Protein name: Histone H2A type 1-H

Gene ID: 85235

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q96KK5-P27958	biogrid,HPIDB	22810585	affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 1.000).	Show
DDI evidence:	yes (score 0.081).	Show
Machine learning evidence:	yes (score 0.133).

Combined Score: 0.999

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-5.77	1.29e-03	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	down	-2.26	6.19e-03	RNA-Seq data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	down	-1.58	2.88e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-2.35	4.66e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	down	-1.88	6.10e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-1.61	2.55e-06	Microarray data
GSE92496	control_vector	HPV16_E6-E7_vector	up	1.98	1.54e-09	RNA-Seq data
GSE93385	K048_mock_infected	K048_ZIKV_infected	down	-2.66	4.17e-33	RNA-Seq data
GSE65574	MCL001_mock_0h	MCL001_d3-5-MERS_0h	down	-2.14	3.59e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-3.37	2.69e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-3.07	3.00e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-2.44	6.25e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-1.65	6.46e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	down	-1.92	3.92e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	down	-1.61	1.42e-02	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-2.37	6.15e-03	Microarray data
GSE87750-GPL16791	hNCC_mock_infected	hNCC_ZIKV-PRVABC59_infected	down	-4.84	1.73e-04	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	down	-1.53	1.19e-05	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	down	-1.59	1.47e-10	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-1.67	5.30e-16	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	down	-2.43	4.73e-21	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	up	1.64	2.66e-04	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	3.24	7.85e-22	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	2.30	2.16e-11	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	2.41	6.23e-16	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	2.07	9.29e-08	RNA-Seq data
GSE93861	healthy_blood_control	Ebola_infection	up	3.18	5.54e-15	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
bone marrow	7.4

Ensembl ID:	ENSG00000274997
Gene description:	Histone cluster 1 H2A family member h
Chromosome:	6
Position	27147129-27147515
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location: