Q969H0 (FBXW7)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: FBXW7_HUMAN

UniProtID: Q969H0

Gene name(s): FBXW7;FBW7;FBX30;SEL10

Protein name: F-box/WD repeat-containing protein 7

Gene ID: 55294

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q969H0-P27958biogrid,HPIDB26774344affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.067).
Combined Score: 0.036


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1215Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1)40.25 (1/4)11585921CORUMView
1253Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1)40.25 (1/4)11565034CORUMView
5194TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2)100.20 (2/10)14743216CORUMView
6248FBXW7-CSF3R-GSK3B complex30.33 (1/3)23820376CORUMView
6906FBXW7-CDX2-GSK3B complex30.33 (1/3)27470268CORUMView
6975JUN-FBW7-PRR7 complex30.67 (2/3)27458189CORUMView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE102481mock_infected_18hRVFV_MP12_infected_18hup3.776.51e-40RNA-Seq data
GSE102481mock_infected_18hRVFV_ZH548_infected_18hup3.091.95e-22RNA-Seq data
GSE28166mock_infected_12hVN1203_infected_12hdown-2.131.87e-03Microarray data
GSE28166mock_infected_18hVN1203_infected_18hdown-3.243.43e-03Microarray data
GSE28166mock_infected_24hVN1203_infected_24hdown-2.783.81e-05Microarray data
GSE46041iPS-derived_neurons_uninfectediPS-derived_neurons_HSV-1-infectedup1.882.75e-04Microarray data
GSE48121PANC-1_cells_controlPANC-1_cells_GLV-1h153_infection_6hup2.112.02e-07Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_NL219_pCalu3_24hdown-3.033.33e-06Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hdown-2.941.76e-06Microarray data
GSE65574MCL001_mock_12hMCL001_d3-5-MERS_12hup1.865.11e-04Microarray data
GSE65574MCL001_mock_24hMCL001_d3-5-MERS_24hup2.702.27e-04Microarray data
GSE65574MCL001_mock_24hMCL001_d4B-MERS_24hup1.712.29e-03Microarray data
GSE65574MCL001_mock_24hMCL001_RFP-MERS_24hup1.751.25e-02Microarray data

Human tissue specific expression (TPM)

Small intestine: 11.8 Liver: 6.1 Gallbladder: 14.4 Duodenum: 9.1 Rectum: 12.1 Tonsil: 19.1 Stomach: 13.0 Salivary glanda: 4.7 Adipose tissue: 17.0 Lung: 14.1 Lymph node: 19.1 Pancreas: 2.3 Kidney: 6.5 Colon: 9.8 Appendix: 20.4 Smooth musle: 13.9 Breast: 18.9 Parathyroid gland: 16.6 Esophagus: 16.4 Heart muscle: 11.8 Spleen: 19.8 Skeletal muscle: 10.5 Bone marrow: 13.3 Skin: 87.4 Urinary bladder: 14.1 Cervix, uterine: 13.1 Endometrium: 14.6 Ovary: 11.3 Fallopian tube: 26.3 Seminal vesicle: 10.6 Prostate: 11.9 Epididymis: 35.5 Testis: 45.2 Placenta: 14.3 Thyroid gland: 16.6 Cerebral cortex: 74.6 Adrenal gland: 13.4
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000109670
Gene description:F-box and WD repeat domain containing 7
Chromosome:4
Position152321259-152536101
Protein class:Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm, Vesicles