HVIDB-PPI detail

Q93077 (HIST1H2AC)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: H2A1C_HUMAN

UniProtID: Q93077

Gene name(s): HIST1H2AC;H2AFL

Protein name: Histone H2A type 1-C

Gene ID: 8334

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q93077-P27958	biogrid,HPIDB	22810585	affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 1.000).	Show
DDI evidence:	yes (score 0.081).	Show
Machine learning evidence:	yes (score 0.141).

Combined Score: 0.999

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE62546	Huh7.5_control	APC140_HCV2a_infected	down	-1.71	3.08e-06	Microarray data
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-3.66	8.71e-16	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	down	-3.19	2.44e-06	RNA-Seq data
GSE84188	mock_infected_1d	EBOV_infected_1d	up	2.53	1.44e-02	RNA-Seq data
GSE84188	mock_infected_2d	EBOV_infected_2d	up	2.92	2.59e-18	RNA-Seq data
GSE84188	mock_infected_2d	RESTV_infected_2d	up	2.79	2.55e-04	RNA-Seq data
GSE19345	Mock_infected	HCMV_infected_24h	down	-1.85	4.47e-05	Microarray data
GSE24362	EBNA3CHT_LCL_C51_HT+_7d_non-permissive	EBNA3CHT_LCL_C51_EBNA3C_transcomplemented	down	-2.06	4.05e-03	Microarray data
GSE24362	EBNA3CHT_LCL_C51_HT+_7d_permissive	EBNA3CHT_LCL_C51_EBNA3C_transcomplemented	down	-1.86	5.84e-03	Microarray data
GSE30723	AMs_control_24h	AMs_PR8_24h	up	2.60	2.41e-03	Microarray data
GSE30723	ATII_control_24h	ATII_PR8_24h	up	1.58	3.27e-02	Microarray data
GSE32140-GPL6947	mock_for_RSV_2h	RSV_infection_2h	up	1.79	1.28e-02	Microarray data
GSE49628	Bcells_Quiescent	Bcells_Activation	down	-2.03	8.98e-03	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	up	1.89	2.55e-02	Microarray data
GSE59226	Control	Virus_infection	down	-2.52	1.48e-04	Microarray data
GSE67198	uninfected_control	150HA_u_per_mL_Sev_infected	up	1.58	7.74e-06	Microarray data
GSE71673	SK-N-SH_control_72h	Enterovirus_A71_72h	up	1.90	4.59e-05	Microarray data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	down	-1.82	1.09e-20	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_72hrs	down	-1.52	2.89e-09	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_24h	up	2.76	1.80e-04	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000180573
Gene description:	Histone cluster 1 H2A family member c
Chromosome:	6
Position	26124145-26139116
Protein class:	Cancer-related genes, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location: