Q92793 (CREBBP)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: CBP_HUMAN

UniProtID: Q92793

Gene name(s): CREBBP;CBP

Protein name: CREB-binding protein

Gene ID: 1387

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q92793-P27958biogrid,HPIDB15380363pull down

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: yes (score 0.030). Show
Machine learning evidence: yes (score 0.311).
Combined Score: 0.885


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
2638HES1 promoter corepressor complex60.33 (2/6)15546612CORUMView
2641CREBBP-KAT2B-MYOD1 complex30.33 (1/3)9659901CORUMView
2727SRC-3 complex70.29 (2/7)11971985CORUMView
2728SRC-1 complex40.25 (1/4)11971985CORUMView
2829RSmad complex100.30 (3/10)16751102CORUMView
2958SMAD1-CBP complex20.50 (1/2)10673036CORUMView
3061RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying60.17 (1/6)9710619CORUMView
3062RNA polymerase II complex, (CBP, RPBI, PCAF, BAF47), chromatin structure modifying40.25 (1/4)9710619CORUMView
3066RNA polymerase II complex, chromatin structure modifying130.08 (1/13)9710619CORUMView
3137MASH1 promoter-coactivator complex90.33 (3/9)15607978CORUMView
3142CAMK2-delta-MASH1 promoter-coactivator complex80.25 (2/8)15607978CORUMView
3749CREBBP-SMAD2 hexameric complex21.00 (2/2)17283070CORUMView
3750CREBBP-SMAD3 hexameric complex21.00 (2/2)17283070CORUMView
3753CREBBP-SMAD2-SMAD4 pentameric complex30.67 (2/3)17283070CORUMView
3754CREBBP-SMAD3-SMAD4 pentameric complex30.67 (2/3)17283070CORUMView
4Multisubunit ACTR coactivator complex40.50 (2/4)9267036CORUMView
5198CBP-RARA-RXRA-DNA complex, ligand stimulated30.33 (1/3)8616895CORUMView
5264TCF4-CTNNB1-CREBBP complex30.33 (1/3)15782138CORUMView
5573Stat1-alpha-dimer-CBP DNA-protein complex21.00 (2/2)8986769CORUMView
570p300-CBP-p270-SWI/SNF complex70.29 (2/7)9584200CORUMView
571p300-CBP-p270 complex30.67 (2/3)8995708CORUMView
6590FOXO3-CBP complex20.50 (1/2)22474372CORUMView
2565CDKN3-CREBBP-RBL1-CDK240.25 (1/4)NAhu.MAPView
3285p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex150.13 (2/15)NAhu.MAPView
3691MAPK15-CREBBP-RBL1-CDK240.25 (1/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE102481mock_infected_18hRVFV_MP12_infected_18hup2.627.74e-21RNA-Seq data
GSE102481mock_infected_18hRVFV_ZH548_infected_18hup2.943.36e-22RNA-Seq data
GSE28166mock_infected_24hVN1203_infected_24hup1.522.09e-04Microarray data
GSE45042ELC001_mock_infected_24hECL001_EMC_infected_24hdown-1.545.68e-05Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_Anhui01_pCalu3_24hup2.541.67e-07Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hup2.265.07e-04Microarray data
GSE65574MCL001_mock_12hMCL001_icMERS_12hup1.603.07e-02Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hup2.231.18e-03Microarray data
GSE65574MCL001_mock_24hMCL001_d3-5-MERS_24hup1.752.40e-04Microarray data
GSE65574MCL001_mock_24hMCL001_d4B-MERS_24hup3.171.38e-04Microarray data
GSE65574MCL001_mock_24hMCL001_dNSP16-MERS_24hup1.632.61e-03Microarray data
GSE65574MCL001_mock_24hMCL001_icMERS_24hup2.221.21e-02Microarray data
GSE65574MCL001_mock_24hMCL001_RFP-MERS_24hup1.602.53e-02Microarray data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hup2.142.18e-25RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_12hMDM-513_H5N1_MOI2_12hup1.941.19e-18RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 15.3 Liver: 7.4 Gallbladder: 26.2 Duodenum: 12.6 Rectum: 15.5 Tonsil: 19.2 Stomach: 15.4 Salivary glanda: 7.3 Adipose tissue: 19.7 Lung: 23.8 Lymph node: 21.0 Pancreas: 6.2 Kidney: 13.5 Colon: 13.9 Appendix: 22.9 Smooth musle: 29.5 Breast: 19.7 Parathyroid gland: 46.5 Esophagus: 18.2 Heart muscle: 9.4 Spleen: 28.8 Skeletal muscle: 10.2 Bone marrow: 34.1 Skin: 23.4 Urinary bladder: 17.5 Cervix, uterine: 32.5 Endometrium: 43.8 Ovary: 46.2 Fallopian tube: 37.1 Seminal vesicle: 22.8 Prostate: 26.4 Epididymis: 15.1 Testis: 61.7 Placenta: 24.1 Thyroid gland: 39.1 Cerebral cortex: 22.1 Adrenal gland: 14.1
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000005339
Gene description:CREB binding protein
Chromosome:16
Position3725054-3880726
Protein class:Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm, Nuclear bodies