HVIDB-PPI detail

Q92597 (NDRG1)

Homo sapiens

P27958-PRO_0000037576 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: NDRG1_HUMAN

UniProtID: Q92597

Gene name(s): NDRG1;CAP43;DRG1;RTP

Protein name: Protein NDRG1

Gene ID: 10397

HDF/HRF: NA

Virus protein: Non-structural protein 5A(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037576

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q92597-P27958-PRO_0000037576	HPIDB	15607035	two hybrid

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	yes (score 0.008).	Show
Machine learning evidence:	yes (score 0.647).

Combined Score: 1.000

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE100839	mock_infected	EBOV_infected	up	2.07	1.54e-92	RNA-Seq data
GSE13637	HUVEC_control	PR8-infected_IKK2kd-transfected_HUVEC	up	1.61	6.62e-04	Microarray data
GSE24362	EBNA3CHT_LCL_C15_HT+_7d_non-permissive	EBNA3CHT_LCL_C15_EBNA3C_transcomplemented	up	1.78	9.71e-04	Microarray data
GSE24362	EBNA3CHT_LCL_C15_HT+_7d_permissive	EBNA3CHT_LCL_C15_EBNA3C_transcomplemented	up	1.83	3.80e-04	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	1.61	6.60e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	1.83	1.33e-03	Microarray data
GSE32155	CRL-5810_unifected	CRL-5807_infected	up	3.42	9.21e-05	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-2.36	1.01e-04	Microarray data
GSE49628	Bcells_Quiescent	Bcells_Activation	down	-2.88	1.47e-04	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	down	-3.20	7.10e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_12h	Hu_Pan99_pCalu3_12h	down	-1.77	2.03e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	down	-1.65	5.31e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-3.44	3.45e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	down	-5.44	2.05e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-2.77	3.70e-06	Microarray data
GSE50938	extracted_total_RNA_mock-infected_NHDFs	extracted_total_RNA_HCMV-infected_HNDFs_48h_post-infection	up	1.55	6.07e-05	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	up	1.73	4.05e-03	Microarray data
GSE58278	MDDCs_unifected_0h	MDDCs_Dengue_infected_12h	up	2.26	3.66e-03	Microarray data
GSE58278	MDDCs_unifected_0h	MDDCs_Dengue_infected_18h	up	2.21	7.09e-03	Microarray data
GSE58278	MDDCs_unifected_0h	MDDCs_Dengue_infected_24h	up	1.92	1.14e-02	Microarray data
GSE58278	MDDCs_unifected_0h	MDDCs_Dengue_infected_6h	up	1.95	1.60e-02	Microarray data
GSE59226	Control	Virus_infection	down	-2.02	1.25e-03	Microarray data
GSE64605	HS_unifected	HS_Q70_or_M91_infected	up	2.20	8.82e-06	Microarray data
GSE64605	HS_unifected	HS_R70_or_L91_infected	up	2.43	4.53e-06	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-1.86	1.01e-03	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-2.41	3.79e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-1.75	3.43e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	down	-2.14	2.32e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	down	-2.44	5.21e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-1.90	6.97e-03	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-1.55	1.66e-02	Microarray data
GSE99298	mock_infected_0h	hRSV_NS1_Y125A_infected_96h	down	-1.60	2.26e-02	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_12h	HTBE_H1N1_MOI5_infected_12h	down	-1.92	5.33e-18	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_12h	HTBE_H3N2_MOI5_infected_12h	down	-1.97	3.46e-18	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.11	1.99e-58	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000104419
Gene description:	N-myc downstream regulated 1
Chromosome:	8
Position	133237171-133302022
Protein class:	Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Microtubules, Cytosol