HVIDB-PPI detail

Q8TEX9 (IPO4)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: IPO4_HUMAN

UniProtID: Q8TEX9

Gene name(s): IPO4;IMP4B;RANBP4

Protein name: Importin-4

Gene ID: 79711

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q8TEX9-P27958	PHISTO	17616579	Other Methods

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	yes (score 0.048).	Show
Machine learning evidence:	yes (score 0.079).

Combined Score: 0.258

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1149	Histone H3.1 complex	10	0.20 (2/10)	14718166	CORUM	View
1150	Histone H3.3 complex	9	0.22 (2/9)	14718166	CORUM	View
6149	Codanin-1-Asf1u2013histone H3.1-histone H4u2013importin-4 complex, cytosolic	5	0.40 (2/5)	22407294	CORUM	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE68673	A549_uninfected	A549_infected	down	-1.76	4.35e-08	RNA-Seq data
GSE75699	HNBE_control_0h	HNBE_infected_8h	down	-1.69	8.69e-03	RNA-Seq data
GSE84188	mock_infected_1d	EBOV_infected_1d	up	3.20	3.61e-02	RNA-Seq data
GSE85493	MeWo_uninfected_12h	MeWo_pOka-WT_infected_12h	down	-3.79	1.89e-24	RNA-Seq data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-1.79	3.22e-03	Microarray data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-1.90	1.34e-04	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-1.98	2.19e-03	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-2.06	8.86e-04	Microarray data
GSE40711	mock_infected_6h	IDN3006_or_cl2PA_infected_6h	down	-1.82	1.63e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	down	-2.97	3.64e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-1.97	4.92e-07	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-2.04	2.64e-06	Microarray data
GSE85493	MeWo_uninfected_12h	MeWo_Y881-920F_infected_12h	down	-3.70	1.69e-55	RNA-Seq data
GSE59226	Control	Virus_infection	down	-3.03	1.09e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-2.24	1.33e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-3.13	1.15e-05	Microarray data
GSE65574	MCL001_mock_7h	MCL001_RFP-MERS_7h	down	-1.76	3.33e-02	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_24h	HTBE_H1N1_MOI5_infected_24h	down	-1.90	1.66e-07	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-1.61	8.35e-07	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_Both_InfluenzaVirus_and_RhinoVirus_72hrs	down	-1.52	2.43e-08	Microarray data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_03h	MDM-418_H3N2_MOI2_03h	up	1.64	4.66e-04	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_InfluenzaVirus_72hrs	down	-1.58	3.11e-13	Microarray data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	up	1.72	3.30e-04	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
testis	17.4

Ensembl ID:	ENSG00000196497
Gene description:	Importin 4
Chromosome:	14
Position	24180219-24188964
Protein class:	Predicted intracellular proteins, Transporters
Evidence:	Evidence at protein level
Subcellular location:	Cytosol