HVIDB-PPI detail

Q8TED1 (GPX8)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: GPX8_HUMAN

UniProtID: Q8TED1

Gene name(s): GPX8;UNQ847/PRO1785

Protein name: Probable glutathione peroxidase 8

Gene ID: 493869

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q8TED1-P27958	biogrid,HPIDB	23929719	bioid

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.138).

Combined Score: 0.108

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
2016	GPX8-C3orf58	2	0.50 (1/2)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-2.65	3.67e-17	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	down	-3.11	9.25e-11	RNA-Seq data
GSE15520	Naive_Huh7	Norwalk_virus_HG23	down	-2.20	1.13e-04	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	down	-2.84	1.86e-06	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	down	-2.23	3.81e-03	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	down	-1.71	6.15e-05	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-1.74	4.87e-05	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	down	-2.32	2.40e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-1.89	1.27e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	down	-2.27	2.01e-05	Microarray data
GSE50938	extracted_total_RNA_mock-infected_NHDFs	extracted_total_RNA_HCMV-infected_HNDFs_48h_post-infection	down	-2.79	9.90e-06	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	down	-1.61	2.77e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	down	-2.99	1.34e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-3.55	1.97e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	down	-2.88	4.81e-03	Microarray data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	7.88	2.74e-09	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_icMERS_24h	down	-2.98	5.21e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-3.52	6.10e-03	Microarray data
GSE99389	CD4+_mock_infected_4d	EBOV_infected_4d	up	7.47	6.60e-08	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_06h	MDM-315_H1N1_MOI2_06h	up	1.73	2.65e-02	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	1.89	1.19e-06	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	up	3.02	2.43e-03	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	up	3.77	2.39e-03	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	up	1.94	4.24e-02	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	1.74	3.76e-03	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	3.14	5.63e-07	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	3.11	2.36e-06	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000164294
Gene description:	Glutathione peroxidase 8 (putative)
Chromosome:	5
Position	55160118-55167071
Protein class:	Enzymes, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Actin filaments, Cytosol