HVIDB-PPI detail

Homo sapiens

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Human protein: DEN6B_HUMAN

UniProtID: Q8NEG7

Gene name(s): DENND6B;FAM116B

Protein name: Protein DENND6B

Gene ID: 414918

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q8NEG7-P27958-PRO_0000037566	HPIDB	23487458	protein array

Evidence suggesting a protein interaction:

Combined Score: 0.064

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	up	3.57	3.97e-02	RNA-Seq data
GSE79968	IMR90_GFP_48h	IMR90_MCPyV_ST_48h	down	-1.51	2.24e-03	RNA-Seq data
GSE84188	mock_infected_1d	EBOV_infected_1d	down	-1.87	1.52e-03	RNA-Seq data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	down	-2.35	2.93e-04	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	down	-3.16	4.01e-02	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	down	-1.67	4.27e-06	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	up	2.69	2.92e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	up	1.91	1.23e-03	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	up	1.80	2.26e-02	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	2.03	1.24e-09	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	2.32	8.19e-10	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue	Expression (TPM)
fallopian tube	21.5

Ensembl ID:	ENSG00000205593
Gene description:	DENN domain containing 6B
Chromosome:	22
Position	50309030-50327060
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Plasma membrane