HVIDB-PPI detail

Q8NBT2 (SPC24)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: SPC24_HUMAN

UniProtID: Q8NBT2

Gene name(s): SPC24;SPBC24

Protein name: Kinetochore protein Spc24

Gene ID: 147841

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q8NBT2-P27958-PRO_0000037566	HPIDB	23487458	protein array

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	yes (score 0.014).	Show
Machine learning evidence:	yes (score 0.734).

Combined Score: 1.000

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
127	NDC80 kinetochore complex	4	0.25 (1/4)	14699129	CORUM	View
7542	KNL1-MIS12-NDC80-SPC24-ZWINT complex	5	0.20 (1/5)	15824131	CORUM	View
3356	Mis12 centromere complex	11	0.09 (1/11)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-1.61	8.96e-08	RNA-Seq data
GSE78711-GPL15520	NPC_mock_infected	NPC_Zika_infected	down	-2.32	3.48e-05	RNA-Seq data
GSE78711-GPL18573	NPC_mock_infected	NPC_Zika_infected	down	-1.75	7.31e-15	RNA-Seq data
GSE84188	mock_infected_2d	EBOV_infected_2d	down	-9.71	2.50e-11	RNA-Seq data
GSE84285	A549_mock_infected_36h	A549_Dengue_virus_infected_36h	down	-1.64	3.76e-05	RNA-Seq data
GSE28166	mock_infected_12h	VN1203_infected_12h	down	-1.50	3.64e-04	Microarray data
GSE28166	mock_infected_18h	VN1203_infected_18h	down	-1.95	1.84e-03	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	down	-1.90	4.19e-04	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	down	-1.70	3.49e-04	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-2.07	4.98e-04	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	down	-2.69	8.86e-04	Microarray data
GSE49628	Bcells_Quiescent	Bcells_Activation	up	1.72	3.88e-05	Microarray data
GSE49628	Bcells_Quiescent	Bcells_EBV_transformed	up	1.52	1.87e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	down	-2.96	3.71e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	down	-1.88	4.68e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-2.52	6.40e-06	Microarray data
GSE93385	K048_mock_infected	K048_ZIKV_infected	down	-1.52	2.22e-09	RNA-Seq data
GSE97949	uninfected_0h	H7N9_infected_7h	down	-1.91	8.63e-15	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_18h	HTBE_H1N1_MOI5_infected_18h	up	1.73	1.19e-09	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	down	-2.05	6.20e-06	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	down	-3.07	8.21e-13	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	5.03	2.15e-04	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000161888
Gene description:	SPC24, NDC80 kinetochore complex component
Chromosome:	19
Position	11131520-11155808
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleus, Nucleoli