Q8N6M0 (OTUD6B)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: OTU6B_HUMAN

UniProtID: Q8N6M0

Gene name(s): OTUD6B;DUBA5;CGI-77

Protein name: Deubiquitinase OTUD6B

Gene ID: 51633

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q8N6M0-P27958PHISTO23487458protein array

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: yes (score 0.007). Show
Machine learning evidence: yes (score 0.101).
Combined Score: 0.081


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1726OTUD6B-OTUB120.50 (1/2)NAhu.MAPView
3184OTUD6B-DNAJC1720.50 (1/2)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE30723AMs_control_24hAMs_PR8_24hdown-1.981.57e-02Microarray data
GSE31524H1N1_Mock_infection_10hH1N1_infection_10hdown-2.411.80e-03Microarray data
GSE32155CRL-5810_unifectedCRL-1472_infectedup1.521.50e-03Microarray data
GSE32155CRL-5810_unifectedCRL-5807_infectedup1.715.30e-04Microarray data
GSE46041iPS-derived_neurons_uninfectediPS-derived_neurons_HSV-1-infectedup1.722.89e-04Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hdown-1.787.75e-06Microarray data
GSE59226ControlVirus_infectiondown-1.707.10e-04Microarray data

Human tissue specific expression (TPM)

Small intestine: 5.8 Liver: 3.1 Gallbladder: 7.5 Duodenum: 5.3 Rectum: 6.8 Tonsil: 6.3 Stomach: 4.7 Salivary glanda: 1.9 Adipose tissue: 7.5 Lung: 8.5 Lymph node: 9.9 Pancreas: 0.8 Kidney: 6.4 Colon: 4.9 Appendix: 10.6 Smooth musle: 10.1 Breast: 9.0 Parathyroid gland: 9.6 Esophagus: 8.0 Heart muscle: 5.3 Spleen: 8.0 Skeletal muscle: 4.1 Bone marrow: 3.6 Skin: 7.6 Urinary bladder: 8.0 Cervix, uterine: 7.0 Endometrium: 11.1 Ovary: 6.1 Fallopian tube: 6.4 Seminal vesicle: 8.1 Prostate: 9.5 Epididymis: 5.6 Testis: 13.0 Placenta: 12.2 Thyroid gland: 10.9 Cerebral cortex: 17.2 Adrenal gland: 8.0
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000155100
Gene description:OTU domain containing 6B
Chromosome:8
Position91070196-91087095
Protein class:Enzymes, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm, Golgi apparatus, Cytosol