HVIDB-PPI detail

Homo sapiens

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Human protein: MS3L1_HUMAN

UniProtID: Q8N5Y2

Gene name(s): MSL3;MSL3L1

Protein name: Male-specific lethal 3 homolog

Gene ID: 10943

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q8N5Y2-P27958-PRO_0000037566	HPIDB	23487458	protein array

Evidence suggesting a protein interaction:

Combined Score: 0.122

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
610	MSL complex	4	0.25 (1/4)	16227571	CORUM	View
7220	MSL complex	4	0.25 (1/4)	20018852	CORUM	View
2438	MSL3-MSL1	2	0.50 (1/2)	NA	hu.MAP	View
4065	MSL complex	5	0.20 (1/5)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	1.68	3.42e-04	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	down	-2.10	3.60e-03	Microarray data
GSE40711	mock_infected_6h	IDN3006_or_cl2PA_infected_6h	down	-1.78	4.77e-02	Microarray data
GSE65123	healthy_seronegative_control	HCV_infected	down	-1.98	3.80e-02	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Ensembl ID:	ENSG00000005302
Gene description:	Male-specific lethal 3 homolog (Drosophila)
Chromosome:	X
Position	11758159-11775753
Protein class:	Plasma proteins, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm