Q8N5I9 (C12orf45)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
Networks viewer (Cytoscape.js) and color tagging feature require Firefox or Chrome browsers to work properly

Human protein: CL045_HUMAN

UniProtID: Q8N5I9

Gene name(s): C12orf45

Protein name: Uncharacterized protein C12orf45

Gene ID: 121053

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q8N5I9-P27958PHISTO23487458protein array

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: yes (score 0.050). Show
Machine learning evidence: yes (score 0.093).
Combined Score: 0.320


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1961C12orf45-CT55-UHRF1BP1L30.33 (1/3)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE32155CRL-5800_unifectedCRL-1472_infecteddown-1.801.83e-05Microarray data
GSE32155CRL-5810_unifectedCRL-1472_infecteddown-1.517.55e-05Microarray data
GSE49628Bcells_QuiescentBcells_Activationup1.692.45e-04Microarray data
GSE49628Bcells_QuiescentBcells_EBV_transformedup1.734.09e-04Microarray data
GSE50938polysomal_RNA_mock-infected_NHDFspolysomal_RNA_HCMV-infected_HNDFs_48h_post-infectionup1.742.66e-02Microarray data
GSE59226ControlVirus_infectiondown-1.727.37e-04Microarray data
GSE65574MCL001_mock_24hMCL001_icMERS_24hup1.502.50e-02Microarray data
GSE97672-GPL16791MDM-418_H3N2_MOI0_06hMDM-418_H3N2_MOI2_06hdown-1.512.29e-07RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_06hMDM-520_H5N1_MOI2_06hdown-2.101.85e-11RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_12hMDM-520_H5N1_MOI2_12hdown-1.844.15e-04RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hdown-1.594.23e-03RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-2.011.18e-08RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 8.0 Liver: 6.6 Gallbladder: 6.7 Duodenum: 10.2 Rectum: 8.3 Tonsil: 9.9 Stomach: 8.8 Salivary glanda: 6.6 Adipose tissue: 9.5 Lung: 6.3 Lymph node: 12.6 Pancreas: 3.5 Kidney: 4.2 Colon: 9.3 Appendix: 14.0 Smooth musle: 9.2 Breast: 8.3 Parathyroid gland: 2.5 Esophagus: 6.9 Heart muscle: 3.5 Spleen: 11.7 Skeletal muscle: 1.1 Bone marrow: 8.1 Skin: 8.5 Urinary bladder: 7.1 Cervix, uterine: 7.9 Endometrium: 8.6 Ovary: 7.1 Fallopian tube: 7.5 Seminal vesicle: 5.9 Prostate: 8.4 Epididymis: 7.6 Testis: 8.3 Placenta: 6.3 Thyroid gland: 10.0 Cerebral cortex: 8.2 Adrenal gland: 9.6
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000151131
Gene description:Chromosome 12 open reading frame 45
Chromosome:12
Position104986310-105074197
Protein class:Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm, Nuclear membrane