Q8IW41 (MAPKAPK5)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: MAPK5_HUMAN

UniProtID: Q8IW41

Gene name(s): MAPKAPK5;PRAK

Protein name: MAP kinase-activated protein kinase 5

Gene ID: 8550

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q8IW41-P27958-PRO_0000037566HPIDB23487458protein array

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.923). Show
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.732).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
7548MAPK6-MAPKAPK5-SEPT7 complex30.33 (1/3)22508986CORUMView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE28166mock_infected_24hVN1203_infected_24hdown-1.851.19e-03Microarray data
GSE59226ControlVirus_infectiondown-2.111.44e-04Microarray data
GSE65574MCL001_mock_24hMCL001_dNSP16-MERS_24hup1.703.26e-03Microarray data
GSE65574MCL001_mock_24hMCL001_RFP-MERS_24hup2.091.02e-02Microarray data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-1.521.22e-15RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 31.0 Liver: 9.9 Gallbladder: 19.3 Duodenum: 25.6 Rectum: 33.8 Tonsil: 17.6 Stomach: 16.9 Salivary glanda: 7.0 Adipose tissue: 16.4 Lung: 26.2 Lymph node: 23.8 Pancreas: 3.5 Kidney: 21.7 Colon: 27.8 Appendix: 24.0 Smooth musle: 27.8 Breast: 25.2 Parathyroid gland: 28.9 Esophagus: 18.4 Heart muscle: 11.1 Spleen: 21.6 Skeletal muscle: 10.1 Bone marrow: 16.9 Skin: 20.3 Urinary bladder: 17.4 Cervix, uterine: 23.3 Endometrium: 26.1 Ovary: 22.2 Fallopian tube: 26.2 Seminal vesicle: 21.9 Prostate: 27.7 Epididymis: 25.1 Testis: 29.7 Placenta: 29.2 Thyroid gland: 32.2 Cerebral cortex: 23.2 Adrenal gland: 25.7
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000089022
Gene description:Mitogen-activated protein kinase-activated protein kinase 5
Chromosome:12
Position111841978-111902238
Protein class:Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Evidence:Evidence at protein level
Subcellular location:Nucleoplasm, Cytosol