HVIDB-PPI detail

Q8IV56 (PRR15)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: PRR15_HUMAN

UniProtID: Q8IV56

Gene name(s): PRR15

Protein name: Proline-rich protein 15

Gene ID: 222171

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q8IV56-P27958	PHISTO	23487458	protein array

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.072).

Combined Score: 0.039

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE84285	A549_mock_infected_24h	A549_Dengue_virus_infected_24h	up	1.53	1.48e-21	RNA-Seq data
GSE84346	uninfected_control	HCV_infected_high_ISG	up	3.90	4.67e-02	RNA-Seq data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	down	-2.89	2.47e-05	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	down	-2.13	1.11e-04	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	5.81	2.39e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	6.86	7.46e-07	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	down	-3.86	3.14e-05	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	down	-3.28	2.44e-04	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_NL219_pCalu3_24h	up	2.00	4.42e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	1.53	2.88e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	1.74	1.65e-05	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	down	-1.55	6.96e-03	Microarray data
GSE53103	HeLa_no_infection	Hela_SV_12h	up	3.21	3.13e-07	Microarray data
GSE53103	HeLa_shmH2A1	HeLa_shmH2A1_+SV_6h	up	1.54	1.09e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d3-5-MERS_12h	down	-1.87	3.54e-04	Microarray data
GSE65574	MCL001_mock_12h	MCL001_d4B-MERS_12h	down	-2.13	3.39e-05	Microarray data
GSE65574	MCL001_mock_12h	MCL001_icMERS_12h	down	-1.62	1.60e-02	Microarray data
GSE65574	MCL001_mock_12h	MCL001_RFP-MERS_12h	down	-2.01	7.03e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	3.71	9.22e-04	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_12h	HTBE_H1N1_MOI5_infected_12h	up	1.58	3.25e-02	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_6h	HTBE_H3N2_MOI5_infected_6h	up	3.41	3.64e-09	RNA-Seq data
GSE71766	BEAS-2B_control_48hrs	BEAS-2B_RhinoVirus_48hrs	up	2.10	2.63e-09	Microarray data
GSE89008	HTBE_H1N1_MOI0_mock_infected_24h	HTBE_H1N1_MOI5_infected_24h	up	3.13	7.77e-04	RNA-Seq data
GSE89008	HTBE_H3N2_MOI0_mock_infected_12h	HTBE_H3N2_MOI5_infected_12h	up	3.53	4.32e-06	RNA-Seq data
GSE71766	BEAS-2B_control_60hrs	BEAS-2B_RhinoVirus_60hrs	up	2.75	2.62e-09	Microarray data
GSE71766	BEAS-2B_control_72hrs	BEAS-2B_RhinoVirus_72hrs	up	2.01	4.92e-10	Microarray data
GSE89008	HTBE_H3N2_MOI0_mock_infected_18h	HTBE_H3N2_MOI5_infected_18h	up	3.08	1.75e-03	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_12h	MDM-315_H1N1_MOI2_12h	up	7.19	7.20e-03	RNA-Seq data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_48hrs	up	1.60	3.60e-10	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_60hrs	up	2.18	3.35e-10	Microarray data
GSE71766	BEAS-2B_control_baseline	BEAS-2B_RhinoVirus_72hrs	up	1.73	1.25e-11	Microarray data
GSE8961	Mock_infection	HMPV_infection_12h	up	1.69	3.86e-03	Microarray data
GSE8961	Mock_infection	HMPV_infection_24h	up	1.67	2.29e-05	Microarray data
GSE8961	Mock_infection	HMPV_infection_48h	up	1.61	2.79e-03	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
cervix, uterine	91.4

Ensembl ID:	ENSG00000176532
Gene description:	Proline rich 15
Chromosome:	7
Position	29563811-29567295
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Vesicles, Cell Junctions