Q8IUD2 (ERC1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: RB6I2_HUMAN

UniProtID: Q8IUD2

Gene name(s): ERC1;ELKS;KIAA1081;RAB6IP2

Protein name: ELKS/Rab6-interacting/CAST family member 1

Gene ID: 23085

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q8IUD2-P27958PHISTO16033967anti bait coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: yes (score 0.013). Show
Machine learning evidence: yes (score 0.181).
Combined Score: 0.303


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
2118CHUK-ERC1-IKBKB-IKBKG40.50 (2/4)15218148CORUMView
3197RNF10-CD2AP-ERC2-ERC140.50 (2/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE28166mock_infected_12hVN1203_infected_12hdown-1.909.93e-05Microarray data
GSE28166mock_infected_18hVN1203_infected_18hdown-2.656.27e-04Microarray data
GSE28166mock_infected_24hVN1203_infected_24hdown-2.136.58e-04Microarray data
GSE32140-GPL6480mock_for_RSV_2hRSV_infectiondown-1.639.41e-05Microarray data
GSE32155CRL-5800_unifectedCRL-5807_infecteddown-2.383.99e-05Microarray data
GSE32155CRL-5810_unifectedCRL-5807_infecteddown-1.613.21e-04Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_NL219_pCalu3_24hdown-3.471.20e-04Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hdown-4.346.81e-05Microarray data

Human tissue specific expression (TPM)

Small intestine: 2.5 Liver: 1.7 Gallbladder: 5.9 Duodenum: 1.7 Rectum: 3.5 Tonsil: 2.4 Stomach: 2.6 Salivary glanda: 1.8 Adipose tissue: 5.9 Lung: 5.5 Lymph node: 2.8 Pancreas: 0.8 Kidney: 5.2 Colon: 3.4 Appendix: 4.7 Smooth musle: 9.6 Breast: 4.1 Parathyroid gland: 17.1 Esophagus: 6.7 Heart muscle: 4.5 Spleen: 4.0 Skeletal muscle: 1.6 Bone marrow: 2.3 Skin: 5.2 Urinary bladder: 6.0 Cervix, uterine: 7.0 Endometrium: 7.7 Ovary: 6.6 Fallopian tube: 6.8 Seminal vesicle: 8.4 Prostate: 7.7 Epididymis: 2.9 Testis: 7.2 Placenta: 8.7 Thyroid gland: 11.4 Cerebral cortex: 6.8 Adrenal gland: 6.4
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000082805
Gene description:ELKS/RAB6-interacting/CAST family member 1
Chromosome:12
Position990509-1495933
Protein class:Cancer-related genes, Disease related genes, Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Vesicles, Plasma membrane, Cytosol