HVIDB-PPI detail

Q8IUC6 (TICAM1)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Complex structure
Human complex
DEGs post infections
Tissue specific expression

Human protein: TCAM1_HUMAN

UniProtID: Q8IUC6

Gene name(s): TICAM1;PRVTIRB;TRIF

Protein name: TIR domain-containing adapter molecule 1

Gene ID: 148022

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q8IUC6-P27958	PDB	1610791	NA

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	none/insignificant.
Machine learning evidence:	yes (score 0.047).

Combined Score: 0.026

Color:

PPI Site

Human	Virus	PDB/Template	Chain_H	Chain_V	Identity_H	Coverage_H	Identity_V	Coverage_V	Structure_Source
Q8IUC6	P27958	3rc4	A	B	NA	NA	NA	NA	Experimentally verified structure

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1714	TICAM1-TICAM2-TLR4 complex	3	0.33 (1/3)	14519765	CORUM	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE101760	mock_infected	PR8_NS1_infected	up	2.22	1.40e-02	RNA-Seq data
GSE102924	control	ZIKV-Brazil_Dakar_strains	up	1.78	4.13e-07	RNA-Seq data
GSE61141	non-asthmatic_Vehicle	non-asthmatic_HRV16	up	1.68	5.23e-13	RNA-Seq data
GSE75699	HNBE_control_0h	HNBE_infected_24h	up	1.57	1.29e-04	RNA-Seq data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-1.61	8.21e-03	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	up	2.54	3.62e-06	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	3.14	1.59e-03	Microarray data
GSE32155	CRL-5800_unifected	CRL-5807_infected	down	-2.12	8.51e-05	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	up	3.96	4.63e-02	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	2.12	4.90e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Pan99_pCalu3_24h	up	1.88	3.66e-06	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	up	1.59	2.97e-06	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	up	1.51	2.83e-04	Microarray data
GSE99298	mock_infected_0h	hRSV_WT_infected_96h	up	2.01	6.39e-07	RNA-Seq data
GSE89008	HTBE_H1N1_MOI0_mock_infected_3h	HTBE_H1N1_MOI5_infected_3h	up	1.62	1.63e-04	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-1.56	4.85e-02	RNA-Seq data
GSE97672-GPL16791	MDM-315_H1N1_MOI0_18h	MDM-315_H1N1_MOI2_18h	up	1.52	9.40e-08	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-1.60	1.45e-05	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-1.78	4.74e-09	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-1.97	4.56e-06	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-1.73	3.67e-04	RNA-Seq data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_24h	up	1.53	5.51e-03	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000127666
Gene description:	Toll like receptor adaptor molecule 1
Chromosome:	19
Position	4815932-4831704
Protein class:	Disease related genes, Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleus, Nucleoli, Plasma membrane