HVIDB-PPI detail

Q7Z434 (MAVS)

Homo sapiens

A2T3M4 (NA)

Rotavirus A (isolate RVA/Monkey/South Africa/SA11-H96/1958/G3P5B[2]) (RV-A) (Simian Agent 11 (isolate SI/South Africa/H96/58))

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Interaction information
PPI score
DEGs post infections
Tissue specific expression

Human protein: MAVS_HUMAN

UniProtID: Q7Z434

Gene name(s): MAVS;IPS1;KIAA1271;VISA

Protein name: Mitochondrial antiviral-signaling protein

Gene ID: 57506

HDF/HRF: NA

Virus protein: NSP1_ROTSH (RV-A)

UniProtID: A2T3M4

Gene name(s): NA

Protein name: Non-structural protein 1

Gene ID: 7011353

Viral family: Reoviridae

Interaction	Source database	PubMed ID	Detection method
Q7Z434-A2T3M4	PHISTO,HPIDB,UniProt	24643253	anti bait coimmunoprecipitation

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 0.696).	Show
DDI evidence:	yes (score 0.020).	Show
Machine learning evidence:	yes (score 0.705).

Combined Score: 1.000

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE13637	HUVEC_control	PR8-infected_IKK2kd-transfected_HUVEC	down	-1.86	9.39e-05	Microarray data
GSE13637	HUVEC_control	PR8-infected_pEGZ-transfected_HUVEC	down	-1.85	1.04e-04	Microarray data
GSE27702	control_macrophages	FPV-infected_macrophages	down	-2.74	3.73e-03	Microarray data
GSE27702	control_macrophages	H5N1-infected_macrophages	down	-1.91	2.55e-03	Microarray data
GSE30723	AMs_control_24h	AMs_PR8_24h	down	-2.18	4.90e-04	Microarray data
GSE31524	H1N1_Mock_infection_10h	H1N1_infection_10h	down	-1.85	8.61e-06	Microarray data
GSE32140-GPL6480	mock_for_RSV_2h	RSV_infection	down	-1.84	3.39e-05	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	up	1.72	8.58e-05	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	down	-1.63	3.57e-04	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	down	-2.42	9.23e-05	Microarray data
GSE40711	mock_infected_6h	IDN3006_or_cl2PA_infected_6h	down	-1.54	1.66e-04	Microarray data
GSE45042	ELC001_mock_infected_24h	ECL001_EMC_infected_24h	down	-1.76	4.87e-05	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_VN1203_pCalu3_24h	down	-1.89	2.16e-06	Microarray data
GSE59226	Control	Virus_infection	down	-2.69	1.14e-04	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-2.06	9.43e-21	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.12	1.41e-29	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_06h	MDM-418_H3N2_MOI2_06h	down	-2.65	1.49e-38	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	down	-2.82	4.61e-05	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_18h	MDM-418_H3N2_MOI2_18h	down	-2.20	1.08e-37	RNA-Seq data
GSE97672-GPL16791	MDM-513_H5N1_MOI0_06h	MDM-513_H5N1_MOI2_06h	down	-3.10	4.58e-60	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_06h	MDM-520_H5N1_MOI2_06h	down	-2.74	6.63e-45	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	down	-3.76	6.02e-84	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	down	-3.28	1.46e-53	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	down	-3.65	2.76e-90	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	down	-4.08	4.77e-92	RNA-Seq data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000088888
Gene description:	Mitochondrial antiviral signaling protein
Chromosome:	20
Position	3846799-3876123
Protein class:	Predicted membrane proteins
Evidence:	Evidence at protein level
Subcellular location:	Mitochondria