Q6UB35 (MTHFD1L)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: C1TM_HUMAN

UniProtID: Q6UB35

Gene name(s): MTHFD1L;FTHFSDC1

Protein name: Monofunctional C1-tetrahydrofolate synthase

Gene ID: 25902

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q6UB35-P27958biogrid,HPIDB26845356two hybrid

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.631). Show
DDI evidence: yes (score 0.037). Show
Machine learning evidence: yes (score 0.107).
Combined Score: 0.905


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
2985Ribosome, cytoplasmic1390.12 (16/139)NAhu.MAPView
3487UBQLN1-MTHFD1L21.00 (2/2)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE24587Control_293TetLuc_doxcycline_48hEBV_infected_293TetER_doxycycline_48hdown-1.537.40e-03Microarray data
GSE28166mock_infected_24hVN1203_infected_24hdown-2.142.37e-04Microarray data
GSE32155CRL-5800_unifectedCRL-1472_infecteddown-1.541.25e-04Microarray data
GSE32155CRL-5800_unifectedCRL-5807_infecteddown-2.481.57e-04Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-1.561.00e-04Microarray data
GSE65574MCL001_mock_7hMCL001_RFP-MERS_7hdown-1.982.16e-03Microarray data
GSE66486PBMC_uninfected_controlPBMC_healthy_donor_infected_16hup1.901.32e-02Microarray data
GSE66486PBMC_uninfected_controlPBMC_healthy_donor_infected_8hup2.035.88e-03Microarray data
GSE97672-GPL16791MDM-315_H1N1_MOI0_12hMDM-315_H1N1_MOI2_12hdown-1.811.16e-18RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_12hMDM-418_H3N2_MOI2_12hdown-2.262.77e-03RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_18hMDM-418_H3N2_MOI2_18hdown-3.091.00e-16RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 3.7 Liver: 1.9 Gallbladder: 9.5 Duodenum: 3.3 Rectum: 9.0 Tonsil: 10.0 Stomach: 4.0 Salivary glanda: 0.7 Adipose tissue: 11.2 Lung: 12.8 Lymph node: 12.9 Pancreas: 2.2 Kidney: 5.5 Colon: 5.6 Appendix: 16.0 Smooth musle: 14.4 Breast: 6.2 Parathyroid gland: 10.1 Esophagus: 4.8 Heart muscle: 2.9 Spleen: 10.7 Skeletal muscle: 0.2 Bone marrow: 8.2 Skin: 5.4 Urinary bladder: 9.6 Cervix, uterine: 8.4 Endometrium: 9.2 Ovary: 13.3 Fallopian tube: 11.6 Seminal vesicle: 9.9 Prostate: 6.2 Epididymis: 7.7 Testis: 18.9 Placenta: 20.6 Thyroid gland: 18.4 Cerebral cortex: 15.2 Adrenal gland: 11.9
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000120254
Gene description:Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Chromosome:6
Position150865549-151101887
Protein class:Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Evidence:Evidence at protein level
Subcellular location:Mitochondria