HVIDB-PPI detail

Q6FI13 (HIST2H2AA3)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

Networks viewer (Cytoscape.js) and color tagging feature require Firefox or Chrome browsers to work properly

Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: H2A2A_HUMAN

UniProtID: Q6FI13

Gene name(s): HIST2H2AA3;H2AFO;HIST2H2AA;;HIST2H2AA4

Protein name: Histone H2A type 2-A

Gene ID: 723790;8337

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q6FI13-P27958	biogrid,HPIDB	22810585	affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 1.000).	Show
DDI evidence:	yes (score 0.081).	Show
Machine learning evidence:	yes (score 0.133).

Combined Score: 0.999

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
1728	CTCF-nucleophosmin-PARP-HIS-KPNA-LMNA-TOP complex	9	0.22 (2/9)	14759373	CORUM	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE62546	Huh7.5_control	APC140_HCV2a_infected	down	-1.72	1.24e-06	Microarray data
GSE13637	HUVEC_control	PR8-infected_IKK2kd-transfected_HUVEC	up	2.00	1.25e-05	Microarray data
GSE13637	HUVEC_control	PR8-infected_IKK2kd-transfected_HUVEC	up	2.00	1.25e-05	Microarray data
GSE13637	HUVEC_control	PR8-infected_pEGZ-transfected_HUVEC	up	2.32	3.08e-07	Microarray data
GSE13637	HUVEC_control	PR8-infected_pEGZ-transfected_HUVEC	up	2.32	3.08e-07	Microarray data
GSE14816	TB40E_mock	TB40E_TB	up	2.23	1.00e-04	Microarray data
GSE14816	TB40E_mock	TB40E_TB	up	2.23	1.00e-04	Microarray data
GSE24362	EBNA3CHT_LCL_C51_HT+_7d_non-permissive	EBNA3CHT_LCL_C51_EBNA3C_transcomplemented	down	-1.50	1.56e-02	Microarray data
GSE24362	EBNA3CHT_LCL_C51_HT+_7d_non-permissive	EBNA3CHT_LCL_C51_EBNA3C_transcomplemented	down	-1.50	1.56e-02	Microarray data
GSE28166	mock_infected_24h	VN1203_infected_24h	up	1.53	6.98e-04	Microarray data
GSE30723	AMs_control_24h	AMs_PR8_24h	up	3.65	1.18e-03	Microarray data
GSE30723	AMs_control_24h	AMs_PR8_24h	up	3.65	1.18e-03	Microarray data
GSE30723	AMs_control_4h	AMs_PR8_4h	up	1.60	4.08e-02	Microarray data
GSE30723	AMs_control_4h	AMs_PR8_4h	up	1.60	4.08e-02	Microarray data
GSE30723	ATII_control_24h	ATII_PR8_24h	up	2.47	1.16e-02	Microarray data
GSE30723	ATII_control_24h	ATII_PR8_24h	up	2.47	1.16e-02	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	1.77	6.99e-05	Microarray data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	1.71	5.21e-03	Microarray data
GSE32140-GPL6947	mock_for_RSV_2h	RSV_infection_2h	up	2.19	8.89e-03	Microarray data
GSE32155	CRL-5800_unifected	CRL-1472_infected	down	-1.83	4.91e-04	Microarray data
GSE32155	CRL-5810_unifected	CRL-1472_infected	down	-2.13	6.02e-04	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	up	1.72	3.90e-04	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	1.75	4.25e-03	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	1.72	3.97e-07	Microarray data
GSE50938	extracted_total_RNA_mock-infected_NHDFs	extracted_total_RNA_HCMV-infected_HNDFs_48h_post-infection	up	2.17	1.38e-05	Microarray data
GSE50938	extracted_total_RNA_mock-infected_NHDFs	extracted_total_RNA_HCMV-infected_HNDFs_48h_post-infection	up	2.17	1.38e-05	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	up	3.21	6.08e-03	Microarray data
GSE50938	polysomal_RNA_mock-infected_NHDFs	polysomal_RNA_HCMV-infected_HNDFs_48h_post-infection	up	3.21	6.08e-03	Microarray data
GSE53103	Namalwa_shscr	Namalwa_shscr_+SV_6h	down	-1.91	1.58e-06	Microarray data
GSE53103	Namalwa_shscr	Namalwa_shscr_+SV_6h	down	-1.91	1.58e-06	Microarray data
GSE64605	HS_unifected	HS_Q70_or_M91_infected	down	-2.20	1.56e-04	Microarray data
GSE64605	HS_unifected	HS_Q70_or_M91_infected	down	-1.96	2.85e-05	Microarray data
GSE64605	HS_unifected	HS_R70_or_L91_infected	down	-1.54	3.96e-04	Microarray data
GSE64605	HS_unifected	HS_R70_or_L91_infected	down	-1.60	4.59e-05	Microarray data
GSE65699	PRE_mock	PRE_infection_RKAA	up	1.87	1.61e-11	Microarray data
GSE65699	PRE_mock	PRE_infection_RKAA	up	1.84	2.21e-10	Microarray data
GSE65699	PRE_mock	PRE_infection_WT	up	2.01	2.82e-12	Microarray data
GSE65699	PRE_mock	PRE_infection_WT	up	1.95	2.76e-11	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	1.62	9.85e-03	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	1.70	5.87e-03	Microarray data
GSE83259	NIKS_control	NIKS_HPV16	down	-1.51	4.81e-04	Microarray data
GSE83259	NIKS_control	NIKS_HPV16	down	-1.51	4.81e-04	Microarray data
GSE93861	healthy_blood_control	Ebola_infection	up	1.88	1.78e-09	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_12h	up	2.34	2.62e-02	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_12h	up	2.34	2.62e-02	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_24h	up	2.78	9.39e-04	Microarray data
GSE980	monocyte-derived_dendritic_cells_control	MV-infected_dendritic_cells_24h	up	2.78	9.39e-04	Microarray data
GSE99858	PBMC_control	PBMC_RV16_infection	up	1.82	1.26e-09	Microarray data
GSE99858	PBMC_control	PBMC_RV16_infection	up	2.14	1.04e-09	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
bone marrow	112.2
prostate	125.6

Ensembl ID:	ENSG00000203812
Gene description:	Histone cluster 2 H2A family member a3
Chromosome:	1
Position	149842188-149842736
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:

Expression value is measured by Transcripts Per Million (TPM)

Tissue enhanced:

Tissue	Expression (TPM)
testis	88.9

Ensembl ID:	ENSG00000272196
Gene description:	Histone cluster 2 H2A family member a4
Chromosome:	1
Position	149851061-149851624
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location: