Q6FHJ7 (SFRP4)

Homo sapiens

P27958-PRO_0000037576 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: SFRP4_HUMAN

UniProtID: Q6FHJ7

Gene name(s): SFRP4;FRPHE

Protein name: Secreted frizzled-related protein 4

Gene ID: 6424

HDF/HRF: NA

Virus protein: Non-structural protein 5A(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037576

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q6FHJ7-P27958-PRO_0000037576HPIDB15607035two hybrid

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.696). Show
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.669).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
73LPP-PPP2CA-PPP2R3A complex40.25 (1/4)NAhu.MAPView
1570SFRP4-PPP2R3A20.50 (1/2)NAhu.MAPView
3510SFRP4-PPP2R3A-LIMD130.33 (1/3)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE84897MKN7_WT_controlMKN7_EBV_infecteddown-10.323.89e-07RNA-Seq data
GSE28166mock_infected_24hVN1203_infected_24hdown-2.171.04e-02Microarray data
GSE32140-GPL6480mock_for_RSV_2hRSV_infectiondown-1.511.00e-05Microarray data
GSE32155CRL-5810_unifectedCRL-1472_infecteddown-14.061.17e-07Microarray data
GSE32155CRL-5810_unifectedCRL-5807_infecteddown-13.101.31e-07Microarray data
GSE46041iPS-derived_neurons_uninfectediPS-derived_neurons_HSV-1-infecteddown-3.431.53e-03Microarray data
GSE93385K048_mock_infectedK048_ZIKV_infectedup2.543.25e-04RNA-Seq data
GSE99298mock_infected_0hhRSV_WT_infected_96hdown-4.244.61e-02RNA-Seq data
GSE68503empty_vector_controltumor-derived_LT339down-2.603.55e-02Microarray data
GSE97672-GPL16791MDM-418_H3N2_MOI0_06hMDM-418_H3N2_MOI2_06hup5.014.83e-02RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_18hMDM-418_H3N2_MOI2_18hup6.511.33e-05RNA-Seq data
GSE97672-GPL16791MDM-513_H5N1_MOI0_06hMDM-513_H5N1_MOI2_06hup9.151.01e-06RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_06hMDM-520_H5N1_MOI2_06hup7.882.96e-04RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_12hMDM-520_H5N1_MOI2_12hup4.986.93e-03RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_18hMDM-520_H5N1_MOI2_18hup5.393.85e-03RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hup8.441.08e-03RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_12hMDM-513_H5N1_MOI2_12hup7.243.14e-03RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 1.5 Liver: 0.3 Gallbladder: 25.8 Duodenum: 1.2 Rectum: 2.8 Tonsil: 1.8 Stomach: 0.7 Salivary glanda: 1.6 Adipose tissue: 32.0 Lung: 18.4 Lymph node: 8.3 Pancreas: 1.0 Kidney: 3.2 Colon: 3.1 Appendix: 1.8 Smooth musle: 130.5 Breast: 50.4 Parathyroid gland: 2.8 Esophagus: 2.4 Heart muscle: 13.4 Spleen: 13.1 Skeletal muscle: 1.3 Bone marrow: 0.5 Skin: 0.3 Urinary bladder: 50.8 Cervix, uterine: 935.5 Endometrium: 776.1 Ovary: 95.8 Fallopian tube: 338.6 Seminal vesicle: 58.4 Prostate: 24.0 Epididymis: 21.8 Testis: 32.1 Placenta: 0.3 Thyroid gland: 8.0 Cerebral cortex: 2.6 Adrenal gland: 19.7
Expression value is measured by Transcripts Per Million (TPM)
Group enriched:
TissueExpression (TPM)
cervix, uterine 935.5
endometrium 776.1
fallopian tube 338.6
Ensembl ID:ENSG00000106483
Gene description:Secreted frizzled related protein 4
Chromosome:7
Position37905932-38025695
Protein class:Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Evidence:Evidence at protein level
Subcellular location: