Q68E01 (INTS3)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: INT3_HUMAN

UniProtID: Q68E01

Gene name(s): INTS3;C1orf193;C1orf60

Protein name: Integrator complex subunit 3

Gene ID: 65123

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q68E01-P27958-PRO_0000037566HPIDB23487458protein array

Evidence suggesting a protein interaction:

Interolog evidence: none/insignificant.
DDI evidence: none/insignificant.
Machine learning evidence: yes (score 0.182).
Combined Score: 0.200


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
1153Integrator complex120.08 (1/12)16239144CORUMView
1155Integrator-RNAPII complex140.07 (1/14)16239144CORUMView
1694XPO6-TNPO3-TNPO2-TTI1-INTS3-VAC14-VSIG2-ZW10-XPO7-ATR-COG4-THADA120.08 (1/12)NAhu.MAPView
2005INIP-INTS3-NABP1-NABP240.25 (1/4)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE49840Hu_Mock_pCalu3_24hHu_NL219_pCalu3_24hdown-3.321.67e-05Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hdown-2.825.03e-07Microarray data
GSE65574MCL001_mock_12hMCL001_d3-5-MERS_12hdown-1.861.66e-04Microarray data
GSE65574MCL001_mock_12hMCL001_d4B-MERS_12hdown-1.551.88e-04Microarray data
GSE65574MCL001_mock_12hMCL001_icMERS_12hdown-1.851.98e-03Microarray data
GSE65574MCL001_mock_12hMCL001_RFP-MERS_12hdown-1.502.01e-03Microarray data
GSE89008HTBE_H5N1_MOI0_mock_infected_18hHTBE_H5N1_MOI5_infected_18hdown-1.807.25e-12RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_18hMDM-513_H5N1_MOI2_18hdown-1.813.75e-10RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 5.6 Liver: 2.5 Gallbladder: 11.1 Duodenum: 4.3 Rectum: 5.2 Tonsil: 5.8 Stomach: 6.1 Salivary glanda: 2.2 Adipose tissue: 8.3 Lung: 11.0 Lymph node: 7.0 Pancreas: 1.6 Kidney: 6.8 Colon: 4.7 Appendix: 9.0 Smooth musle: 13.6 Breast: 5.3 Parathyroid gland: 15.9 Esophagus: 5.9 Heart muscle: 4.5 Spleen: 9.4 Skeletal muscle: 2.8 Bone marrow: 3.8 Skin: 8.9 Urinary bladder: 7.9 Cervix, uterine: 10.0 Endometrium: 12.5 Ovary: 12.6 Fallopian tube: 16.5 Seminal vesicle: 10.8 Prostate: 9.2 Epididymis: 9.8 Testis: 10.0 Placenta: 10.5 Thyroid gland: 11.3 Cerebral cortex: 10.9 Adrenal gland: 8.7
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000143624
Gene description:Integrator complex subunit 3
Chromosome:1
Position153728067-153774808
Protein class:Predicted intracellular proteins, Predicted secreted proteins
Evidence:Evidence at protein level
Subcellular location:Nucleus, Nucleoli