Q53F19 (NCBP3)

Homo sapiens

P27958-PRO_0000037566 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)
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Human protein: NCBP3_HUMAN

UniProtID: Q53F19

Gene name(s): NCBP3;C17orf85

Protein name: Nuclear cap-binding protein subunit 3

Gene ID: 55421

HDF/HRF: NA

Virus protein: Core protein p21(POLG_HCVH) (HCV-H)

UniProtID: P27958-PRO_0000037566

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae


InteractionSource databasePubMed IDDetection method
Q53F19-P27958-PRO_0000037566HPIDB23487458protein array

Evidence suggesting a protein interaction:

Interolog evidence: yes (score 0.696). Show
DDI evidence: yes (score 0.033). Show
Machine learning evidence: yes (score 0.747).
Combined Score: 1.000


Virally targeted human complex

Complex idComplex nameComplex sizeTarget ratioPudMed IDSourceDetail
150TREX complex130.08 (1/13)NAhu.MAPView
1644hTREX84 complex60.17 (1/6)NAhu.MAPView
3367hTREX84 complex110.09 (1/11)NAhu.MAPView

Differentially expression condition

SeriesControlTreatmentRegulationLog2FCAdj.P.ValData type
GSE27702control_macrophagesH5N1-infected_macrophagesdown-1.904.92e-03Microarray data
GSE28166mock_infected_18hVN1203_infected_18hdown-1.783.89e-03Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_NL219_pCalu3_24hdown-2.461.33e-03Microarray data
GSE49840Hu_Mock_pCalu3_24hHu_VN1203_pCalu3_24hdown-4.311.39e-03Microarray data
GSE65574MCL001_mock_12hMCL001_d3-5-MERS_12hup1.673.86e-03Microarray data
GSE89008HTBE_H1N1_MOI0_mock_infected_24hHTBE_H1N1_MOI5_infected_24hup1.951.72e-12RNA-Seq data
GSE89008HTBE_H3N2_MOI0_mock_infected_18hHTBE_H3N2_MOI5_infected_18hup3.701.53e-51RNA-Seq data
GSE97672-GPL16791MDM-418_H3N2_MOI0_12hMDM-418_H3N2_MOI2_12hdown-1.512.98e-02RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_06hMDM-520_H5N1_MOI2_06hdown-1.832.95e-12RNA-Seq data
GSE97672-GPL16791MDM-520_H5N1_MOI0_12hMDM-520_H5N1_MOI2_12hdown-1.732.49e-11RNA-Seq data
GSE97672-GPL18573MDM-513_H5N1_MOI0_12hMDM-513_H5N1_MOI2_12hdown-1.615.76e-09RNA-Seq data

Human tissue specific expression (TPM)

Small intestine: 8.1 Liver: 1.9 Gallbladder: 7.7 Duodenum: 8.5 Rectum: 6.4 Tonsil: 5.0 Stomach: 5.8 Salivary glanda: 2.3 Adipose tissue: 4.7 Lung: 8.0 Lymph node: 7.7 Pancreas: 1.5 Kidney: 3.9 Colon: 5.3 Appendix: 10.6 Smooth musle: 8.6 Breast: 5.7 Parathyroid gland: 10.8 Esophagus: 4.7 Heart muscle: 3.0 Spleen: 8.3 Skeletal muscle: 3.1 Bone marrow: 11.3 Skin: 9.6 Urinary bladder: 3.3 Cervix, uterine: 6.4 Endometrium: 10.1 Ovary: 7.4 Fallopian tube: 7.3 Seminal vesicle: 6.1 Prostate: 7.9 Epididymis: 4.4 Testis: 16.3 Placenta: 10.2 Thyroid gland: 7.0 Cerebral cortex: 9.3 Adrenal gland: 6.3
Expression value is measured by Transcripts Per Million (TPM)
Low tissue specificity
Ensembl ID:ENSG00000074356
Gene description:Nuclear cap binding subunit 3
Chromosome:17
Position3802165-3846251
Protein class:Predicted intracellular proteins
Evidence:Evidence at protein level
Subcellular location:Nuclear speckles