HVIDB-PPI detail

Q16778 (HIST2H2BE)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: H2B2E_HUMAN

UniProtID: Q16778

Gene name(s): HIST2H2BE;H2BFQ

Protein name: Histone H2B type 2-E

Gene ID: 8349

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q16778-P27958	biogrid,HPIDB	8647104	pull down

Evidence suggesting a protein interaction:

Interolog evidence:	none/insignificant.
DDI evidence:	yes (score 0.023).	Show
Machine learning evidence:	yes (score 0.098).

Combined Score: 0.142

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
551	core-histone (H2A/H2B/H3/H4)-TDIF2-TDT complex	6	0.50 (3/6)	12786946	CORUM	View
6737	H2A-H2B-TDIF2-PCNA complex	4	0.50 (2/4)	12786946	CORUM	View
3793	nucleic acid binding	10	0.30 (3/10)	NA	hu.MAP	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-2.71	2.40e-09	RNA-Seq data
GSE102481	mock_infected_18h	RVFV_ZH548_infected_18h	down	-2.16	1.39e-03	RNA-Seq data
GSE84188	mock_infected_1d	EBOV_infected_1d	up	4.02	4.49e-04	RNA-Seq data
GSE84188	mock_infected_2d	EBOV_infected_2d	up	3.26	2.95e-13	RNA-Seq data
GSE84188	mock_infected_2d	RESTV_infected_2d	up	2.13	9.62e-03	RNA-Seq data
GSE19345	Mock_infected	HCMV_infected_12h	down	-1.62	3.27e-04	Microarray data
GSE19345	Mock_infected	HCMV_infected_24h	down	-2.73	3.76e-05	Microarray data
GSE30723	AMs_control_24h	AMs_PR8_24h	up	3.70	7.45e-03	Microarray data
GSE30723	ATII_control_24h	ATII_PR8_24h	up	2.66	8.67e-04	Microarray data
GSE32140-GPL6480	mock_for_influenza_2h	influenza_infection	up	1.95	2.25e-05	Microarray data
GSE32140-GPL6947	mock_for_RSV_2h	RSV_infection_2h	up	2.07	1.42e-02	Microarray data
GSE32155	HTB-3_unifected	HTB-174_infected	up	1.59	8.98e-04	Microarray data
GSE32155	HTB-4_unifected	HTB-174_infected	up	1.52	5.18e-03	Microarray data
GSE48121	PANC-1_cells_control	PANC-1_cells_GLV-1h153_infection_6h	up	2.36	7.13e-08	Microarray data
GSE49840	Hu_Mock_pCalu3_24h	Hu_Anhui01_pCalu3_24h	up	1.65	1.74e-07	Microarray data
GSE53103	Namalwa_shscr	Namalwa_shscr_+SV_6h	down	-1.59	1.90e-05	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-1.74	2.94e-17	RNA-Seq data
GSE97672-GPL16791	MDM-418_H3N2_MOI0_12h	MDM-418_H3N2_MOI2_12h	up	1.59	5.45e-03	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_12h	MDM-520_H5N1_MOI2_12h	up	1.74	1.86e-17	RNA-Seq data
GSE97672-GPL16791	MDM-520_H5N1_MOI0_18h	MDM-520_H5N1_MOI2_18h	up	1.76	1.40e-19	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_18h	MDM-513_H5N1_MOI2_18h	up	1.53	8.11e-12	RNA-Seq data
GSE97672-GPL18573	MDM-513_H5N1_MOI0_12h	MDM-513_H5N1_MOI2_12h	up	1.76	4.41e-22	RNA-Seq data
GSE93861	healthy_blood_control	Ebola_infection	up	2.00	3.44e-14	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Low tissue specificity

Ensembl ID:	ENSG00000184678
Gene description:	Histone cluster 2 H2B family member e
Chromosome:	1
Position	149884459-149886652
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location:	Nucleoplasm, Cytosol