HVIDB-PPI detail

Q16777 (HIST2H2AC)

Homo sapiens

P27958 (NA)

Hepatitis C virus genotype 1a (isolate H) (HCV)

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Interaction information
PPI score
Human complex
DEGs post infections
Tissue specific expression

Human protein: H2A2C_HUMAN

UniProtID: Q16777

Gene name(s): HIST2H2AC;H2AFQ

Protein name: Histone H2A type 2-C

Gene ID: 8338

HDF/HRF: NA

Virus protein: POLG_HCVH (HCV-H)

UniProtID: P27958

Gene name(s): NA

Protein name: Genome polyprotein

Gene ID: NA

Viral family: Flaviviridae

Interaction	Source database	PubMed ID	Detection method
Q16777-P27958	biogrid,HPIDB	22810585	affinity chromatography technology

Evidence suggesting a protein interaction:

Interolog evidence:	yes (score 1.000).	Show
DDI evidence:	yes (score 0.081).	Show
Machine learning evidence:	yes (score 0.141).

Combined Score: 0.999

Virally targeted human complex

Complex id	Complex name	Complex size	Target ratio	PudMed ID	Source	Detail
551	core-histone (H2A/H2B/H3/H4)-TDIF2-TDT complex	6	0.50 (3/6)	12786946	CORUM	View
6737	H2A-H2B-TDIF2-PCNA complex	4	0.50 (2/4)	12786946	CORUM	View

Differentially expression condition

Series	Control	Treatment	Regulation	Log2FC	Adj.P.Val	Data type
GSE102481	mock_infected_18h	RVFV_MP12_infected_18h	down	-3.02	3.06e-09	RNA-Seq data
GSE84188	mock_infected_1d	EBOV_infected_1d	up	3.61	2.26e-03	RNA-Seq data
GSE84188	mock_infected_2d	EBOV_infected_2d	up	3.34	9.96e-12	RNA-Seq data
GSE32140-GPL6947	mock_for_influenza_2h	influenza_infection_2h	up	1.79	1.83e-03	Microarray data
GSE32140-GPL6947	mock_for_RSV_2h	RSV_infection_2h	up	2.12	2.52e-02	Microarray data
GSE46041	iPS-derived_neurons_uninfected	iPS-derived_neurons_HSV-1-infected	up	2.20	2.47e-04	Microarray data
GSE65574	MCL001_mock_0h	MCL001_RFP-MERS_0h	up	1.74	2.34e-02	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d3-5-MERS_24h	down	-2.20	4.19e-04	Microarray data
GSE65574	MCL001_mock_24h	MCL001_d4B-MERS_24h	down	-2.29	1.44e-03	Microarray data
GSE65574	MCL001_mock_24h	MCL001_dNSP16-MERS_24h	down	-2.55	1.02e-02	Microarray data
GSE99389	CD4+_mock_infected_1d	EBOV_infected_1d	up	1.95	7.15e-06	RNA-Seq data
GSE65574	MCL001_mock_24h	MCL001_RFP-MERS_24h	down	-3.14	6.28e-03	Microarray data
GSE99389	CD4+_mock_infected_4d	EBOV_infected_4d	up	1.62	3.98e-02	RNA-Seq data
GSE65699	PRE_mock	PRE_infection_RKAA	up	1.56	1.06e-09	Microarray data
GSE65699	PRE_mock	PRE_infection_WT	up	1.75	5.04e-11	Microarray data
GSE66486	PBMC_uninfected_control	PBMC_healthy_donor_infected_8h	up	1.53	8.77e-03	Microarray data
GSE89008	HTBE_H5N1_MOI0_mock_infected_12h	HTBE_H5N1_MOI5_infected_12h	down	-1.58	1.79e-08	RNA-Seq data
GSE89008	HTBE_H5N1_MOI0_mock_infected_18h	HTBE_H5N1_MOI5_infected_18h	down	-2.12	5.40e-19	RNA-Seq data
GSE93861	healthy_blood_control	Ebola_infection	up	1.81	3.20e-17	Microarray data

Human tissue specific expression (TPM)

Expression value is measured by Transcripts Per Million (TPM)

Tissue enriched:

Tissue	Expression (TPM)
bone marrow	23.8

Ensembl ID:	ENSG00000184260
Gene description:	Histone cluster 2 H2A family member c
Chromosome:	1
Position	149886975-149887364
Protein class:	Predicted intracellular proteins
Evidence:	Evidence at protein level
Subcellular location: